丁苯酞注射液联合依达拉奉对老年急性脑梗死患者 神经功能及血清hs-CRP、NSE 水平的影响

Effect of butylphthalide injection combined with edaravone on neurological function and serum hs-CRP and NSE levels in elderly patients with acute cerebral infarction

摘要:

目的 观察丁苯酞注射液联合依达拉奉对老年急性脑梗死（ACI）患者神经功能及血清超敏C- 反应蛋白（hs-CRP）、神经元特异性烯醇化酶（NSE）水平的影响。方法 选取2015 年1 月—2017 年12 月 在浙江新安国际医院治疗的82 例ACI 患者，按照住院顺序分为联合组和对照组，每组41 例。对照组使用依 达拉奉治疗；联合组在对照组基础上使用丁苯酞注射液。两组疗程均为2 周，比较两组临床疗效、治疗前 后神经功能及血清hs-CRP 和NSE 的变化。结果 联合组患者治疗有效率高于对照组（97.56% VS 87.80%） （P <0.05）；两组患者治疗后6、12、24、48 及72 h 的美国国立卫生研究院卒中量表（NIHSS）评分比较， 采用重复测量设计的方差分析：①不同时间点的NIHSS 评分有差别（F =13.246，P =0.000）；②两组间的 NIHSS 评分有差别（F =22.331，P =0.000），联合组NIHSS 评分较对照组低；③两组NIHSS 评分变化趋势 有差别（F =16.371，P =0.000）。联合组治疗前后血清hs-CRP、NSE 水平变化差值高于对照组（P <0.05）。 结论 在依达拉奉基础上，联合运用丁苯酞注射液治疗ACI 的效果更佳，能减轻神经功能损伤，有效控制机 体的炎症反应，且不会对患者造成不适，安全性更高，值得临床推广。

Abstract:

Objective To observe the effects of butylphthalide injection combined with edaravone on neurological function and serum hs-CRP and NSE levels in elderly patients with acute cerebral infarction. Methods Totally 82 patients with acute cerebral infarction treated in our hospital from January 2015 to December 2017 were divided into combined group and control group according to the order of hospitalization. Both groups were treated with routine treatment. On this basis, the control group was treated with edaravone, and the combined group was treated with butylphthalide injection and edaravone. Both groups were treated for 2 weeks. The clinical therapeutic effects, changes of neurological function, serum hs-CRP and neuron-specific enolase (NSE) were compared between the two groups before and after treatment. Result The effective rate of treatment in the combined group (97.56%) was higher than that in the control group (87.80%) (P < 0.05); the NIHSS scores measured in resting state at 6, 12, 24, 48 and 72 hours after treatment in the two groups were different at different time points (F = 13.246, P = 0.000); the NIHSS scores in resting state of the two groups were different (F = 22.331, P = 0.000); the score of NIHSS in the combined group was lower than that those in the control group (F = 16.371, P = 0.000); the difference values before and after treatment of hs-CRP and NSE in the combined group were higher than (P < 0.05). Conclusion Combined use of butylphthalide injection on the basis of edaravone in the treatment of acute cerebral infarction has better effect, can alleviate nerve function damage, effectively control the body’s inflammatory response, and will not cause obvious discomfort to patients, with higher safety, which is worthy of clinical reference.