变应性鼻炎患者血清IL-34 水平 及与血清炎症因子的相关性

Serum IL-34 level in patients with allergic rhinitis and its relationship with serum inflammatory factor levels

摘要:

目的 探讨变应性鼻炎（AR）患者血清白细胞介素-34（IL-34）水平及其与血清白细胞介 素-4（IL-4）、白细胞介素-6（IL-6）及白细胞介素-10（IL-10）水平的关系，阐明IL-34 在AR 中的临 床意义。方法 选取2018 年1 月—2018 年12 月在江山市人民医院耳鼻喉科治疗的100 例AR 患者作为AR 组， 择选同期100 例健康体检者作为对照组。采用酶联免疫吸附试验测定血清IL-34、IL-4、IL-6 及IL-10 水平。 结果 AR 组血清IL-34、IL-4 及IL-6 水平高于对照组（P <0.05），而IL-10 水平低于对照组（P <0.05）。 与治疗前比较，AR 患者治疗后血清IL-34、IL-4 及IL-6 水平降低（P <0.05），而血清IL-10 水平升高（P <0.05）。 AR 患者血清IL-34 水平与血清IL-4、IL-6 水平呈正相关（r =0.526 和0.573，均P =0.000），与IL-10 水平 呈负相关（r =-0.558，P =0.000）。结论 AR 患者血清IL-34 水平升高，IL-34 通过参与炎症反应参与其发病 过程，对AR 的诊断及疗效评价具有一定的价值。

Abstract:

Objective To investigate the serum level of interleukin-34 (IL-34) in patients with allergic rhinitis(AR) and its relationship with serum IL-4, IL-6 and IL-10 levels in order to elucidate the clinical significance of IL-34 in allergic rhinitis. Methods Totally 100 patients of AR were selected as AR group, and 100 healthy subjects were selected as control group in ENT of Jiangshan People’s Hospital from January 2018 to December 2018. The serum IL-34, IL-4, IL-6, IL-10 levels were determined by enzyme-linked immunosorbent assay (ELISA). Results The levels of serum IL-34, IL-4 and IL-6 in AR group were higher than those in control group (P < 0.05), and the IL-10 level was lower than that in control group (P < 0.05).Compared with patients before treatment, the serum IL-34, IL-4 and IL-6 levels were decreased (P < 0.05), and serum IL-10 levels were increased (P < 0.05) after treatment. The serum IL-34 levels in AR patients were positively correlated with serum IL-4 (r = 0.526)and IL-6(r = 0.573) levels (P < 0.05), and negatively correlated with IL-10 levels(r = -0.558)(P < 0.05). Conclusion Serum IL-34 level is elevated in patients with allergic rhinitis. IL-34 may participate in the pathogenesis of allergic rhinitis by participating in inflammatory reactions, and has certain value in the diagnosis and evaluation of allergic rhinitis.