老年良性阵发性位置性眩晕妇女的骨密度变化

Bone mineral density changes in elderly patients with benign paroxysmal positional vertigo

摘要:

目的 分析特发性良性阵发性位置性眩晕（BPPV）老年妇女的骨密度变化。方法 选取2013 年 6 月—2018 年6 月河南中医药大学第一附属医院收治的62 例BPPV 老年妇女患者作为观察组，并选取同期该 院进行体检的62 例健康老年妇女作为对照组。比较两组临床特点、不同侧别骨密度、25- 羟基维生素D 和 骨代谢标志物水平。结果 两组年龄、体重指数、抽烟、饮酒、规律锻炼、糖尿病及高血压比较，差异无统 计学意义（P >0.05）。两组左耳、右耳及腰椎骨密度T 值比较，差异无统计学意义（P >0.05）；观察组患者左 耳、右耳及腰椎骨密度T 值低于对照组（P <0.05）。观察组患者血清骨钙羟基氮端中分子、骨碱性磷酸酶及 β 胶原降解产物水平高于对照组，而25- 羟基维生素D 水平低于对照组（P <0.05）。结论 BPPV 老年妇女 骨密度水平较低，骨吸收率高。

Abstract:

Objective To analyze the changes of bone mineral density in elderly women with idiopathic benign paroxysmal positional vertigo. Methods A total of 62 elderly patients with idiopathic benign paroxysmal positional vertigo admitted to our hospital from June 2013 to June 2018 were enrolled in the study group. 62 healthy elderly women who came to our hospital for health check during the same period were selected for the control group. The clinical characteristics, bone density of different sides, 25-hydroxyvitamin D and bone metabolism markers were compared between the two groups. Results There were no significant differences in age, body mass index (BMI), smoking, alcohol consumption, regular exercise, diabetes, and hypertension between the two groups (P > 0.05). There was no significant difference in the T value of left ear, right ear and lumbar vertebrae between the observation group and the control group (P > 0.05). The T value of the left ear, right ear and lumbar vertebrae of the observation group were lower than those of the control group (P < 0.05). In the observation group, the serum N-terminal midfragment (N-MID), bone alkaline phosphatase (BALP) and β collagen degradation products (β-CTX) were higher than that in the control group, and the 25-hydroxyvitamin D level was lower. Conclusions Elderly women with idiopathic benign paroxysmal positional vertigo have lower bone mineral density and higher bone resorption rate.