浅谈异分化在放射诱导肺纤维化中的作用

Role of heterogeneous differentiation in radiation-induced pulmonary fibrosis

摘要:

肺纤维化即损伤后的肺上皮细胞为胶原和细胞外基质所取代，其过程不可逆，5 年生存率仅为 20% ～ 30%，患者最终死于肺衰竭。在不同治疗阶段，60% 肺癌患者需接受放射治疗；30% 患者发生肺损伤， 最终可能会诱导纤维化发生。目前对放疗导致的纤维化确切机制缺乏了解，该文主要对放射性肺纤维化的研 究进展，以及笔者正在从事的相关研究进行综述，以期了解发生肺纤维化的可能机制。

Abstract:

Pulmonary fibrosis is that lung epithelial cells after injury is replaced by collagen and extracellular matrix (ECM). This is an irreversible process with only 20% to 30% of 5-year survival rate. It has been reported in the literature that 60% of lung cancer patients need radiation therapy at different treatment stages, and 30% of them have lung injury, which may eventually induce fibrosis. At present, there is lack of understanding of the exact mechanism of fibrosis caused by radiotherapy. This review briefly introduces some advances in radioactive pulmonary fibrosis research and related research that we are doing to understand the possible mechanisms of pulmonary fibrosis.