纳布啡在骨科手术麻醉镇痛中的研究进展

Research progress of nalbuphine in analgesia about orthopedic surgery anesthesia

摘要:

μ 阿片受体激动剂临床应用悠久广泛，多年来作为镇痛的主要药物，因其副作用多而影响镇痛 效果。纳布啡（Nal）是大部κ 阿片受体激动剂和小部分μ 阿片受体拮抗剂，该文探求Nal 在骨科手术麻醉 中的临床应用和研究，以及将来可能的发展方向。综述Nal 药学特性、动物实验、小儿及成人患者关于骨科 手术麻醉方面的用药情况，证实其镇痛可靠且副作用少、安全性高；预测Nal 可用于多种用药方式的镇痛。

Abstract:

Mu opioid receptor agonists have been widely used in clinic for a long time, which have been the main analgesic drugs for many years, with more side effects affecting the analgesic effect. Nalbuphine is a major kappa opioid receptor agonists and a minor mu opioid receptor antagonists. To seek the clinical application and research of nalbuphine in orthopedic surgery anesthesia and the possible future directions, this paper has reviewed the pharmacological characteristics of nalbuphine, animal experiment, the use of drugs in pediatric and adult orthopedic surgery anesthesia. It has been proved that nalbuphine has reliable analgesic effect, fewer side effects and high safety. It will be predicted that nalbuphine can be used in various ways of analgesia and the dosage or mode of administration of nalbuphine need to be further studied.