硫辛酸对糖尿病足Wagner 2、3 级患者 氧化应激与炎症反应的影响

Effects of lipoic acid on oxidative stress and inflammatory response in Wagner classification 2 or 3 diabetic foot patients

摘要:

目的 研究硫辛酸对糖尿病足Wagner 2、3 级患者氧化应激与炎症反应的影响。方法 选取2015 年 8 月—2017 年12 月郴州市第一人民医院内分泌科收治的糖尿病足Wagner 2、3 级患者100 例，将其分为对 照组和观察组，每组50 例，分别行常规治疗和硫辛酸治疗。对比两组疗效、氧化应激及炎症反应因子改善情 况。结果 观察组治疗总有效率高于对照组（P <0.05）；观察组治疗后高级氧化蛋白产物、丙二醛低于对照 组（P <0.05），SOD 高于对照组（P <0.05）；观察组治疗后血管细胞黏附因子-1、成纤维细胞生长因子-2、 肿瘤坏死因子-α、白细胞介素-6 低于对照组（P <0.05）。结论 硫辛酸能促进糖尿病足Wagner 2、3 级患 者溃疡愈合，降低氧化应激与炎症反应因子水平。

Abstract:

Objective To study the effect of lipoic acid on oxidative stress and inflammatory response in patients with Wagner classification 2 or 3 diabetic foot. Methods The selection object for the patients with Wagner classification 2 or 3 diabetic foot from August 2015 to December 2017, according to the principle of computer randomly assignment, 100 patients were divided into two groups, including control group and observation group, 50 for each group, which received routine treatment and lipoic acid, respectively. The treatment effect, oxidative stress and inflammation of two groups was compared. Results Compared with the control group, the total effective rate of Wagner classification 2 or 3 diabetic foot in the observation group was superior (P < 0.05). After treatment, the levels of advanced oxidative protein and malondialdehyde in the observation group were lower than those in the control group (P < 0.05), and SOD was higher than that in the control group (P < 0.05). After treatment, vascular cell adhesion factor-1, fibroblast growth factor-2, tumor necrosis factor-alpha and interleukin-6 in the observation group were lower than those in the control group (P < 0.05). Conclusion Lipoic acid can promote ulcer healing in Wagner grade 2 and 3 diabetic foot patients, and reduce the levels of oxidative stress and inflammatory reaction factors.