子痫前期患者血清STOX1、sFlt-1 与病情及妊娠结局的关系

Relationship between serum STOX1, sFlt-1 and state of illness and pregnancy outcome in patients with preeclampsia

摘要:

目的 探讨子痫前期（PE）患者血清STOX1、可溶性Fms 样酪氨酸激酶-1（sFlt-1）与病情 及妊娠结局的关系。方法 选取2017 年6 月—2018 年6 月于天津市南开医院接受治疗的PE 患者92 例，其 中50 例轻度PE 患者作为轻度PE 组、42 例重度PE 患者作为重度PE 组，另选取同期在该医院进行产检的健 康妊娠女性50 例作为对照组。比较3 组研究对象的平均动脉压、24 h 尿蛋白定量、血清STOX1、sFlt-1 水 平及妊娠结局，分析PE 患者血清STOX1、sFlt-1 水平与平均动脉压、24 h 尿蛋白定量的相关性，分析PE 患 者不良妊娠结局的影响因素。结果 重度PE 组和轻度PE 组平均动脉压、24 h 尿蛋白定量及血清STOX1 和sFlt-1 水平高于对照组（P <0.05），重度PE 组高于轻度PE 组（P <0.05）；重度PE 组胎儿死亡、羊水污 染≥Ⅲ度、胎儿宫内窘迫、HELLP 综合征、胎盘早剥、子痫、心衰及肺水肿发生率均高于对照组和轻度PE 组（P <0.05）；轻、重度PE 组的血清STOX1、sFlt-1 水平与平均动脉压、24 h 尿蛋白定量均呈正相关（P <0.05）； 不同平均动脉压、24 h 尿蛋白定量、STOX1 及sFlt-1 的不良妊娠结局发生率比较，差异有统计学意义（P <0.05）。 结论 PE 患者血清STOX1、sFlt-1 水平与病情及妊娠结局密切相关。

Abstract:

Objective To investigate the relationship between serum STOX1, soluble Fms-like tyrosine kinase-1 (sFlt-1) and state of illness and pregnancy outcome in patients with preeclampsia (PE). Methods Totally 92 patients with PE who were treated in our hospital from June 2017 to June 2018 were enrolled. Among them, 50 patients with mild PE were included in the mild PE group and 42 patients with severe PE were included in the severe PE group. Another 50 healthy pregnant women who underwent maternity examination in the hospital during the same period were selected as healthy control group. The mean arterial pressure, 24 h urine protein quantitation and serum STOX1, sFlt-1 levels and pregnancy outcome were compared in the three groups. The correlation between serum STOX1 and sFlt-1 levels and mean arterial pressure and 24 h urine protein quantitation were analyzed. The influencing factors of adverse pregnancy outcomes in patients with PE were analyzed. Results After t-test, the mean arterial pressure, 24 h urine protein quantitation and serum STOX1, sFlt-1 levels in the severe PE group and the mild PE group were higher than those in the healthy control group (P < 0.05), and those in the severe PE group were higher than those in mild PE group (P < 0.05), and the difference was statistically significant (P < 0.05). After x2-test, the incidence of amniotic fluid pollution ≥ III degree, intrauterine distress and HELLP syndrome in the severe PE group was higher than that in healthy control group and mild PE group, and the difference was statistically significant (P<0.05). Pearson analysis showed that serum STOX1 and sFlt-1 levels were positively correlated with mean arterial pressure and 24 h urine protein quantitation in the mild PE group and the severe PE group (P < 0.05). Univariate analysis showed that there were significant differences in mean arterial pressure, 24 h urinary protein quantification, STOX1 and sFlt-1 by x2-test (P < 0.05). Conclusions The levels of serum STOX1 and sFlt-1 in patients with PE are closely related to the state of illness and pregnancy outcome.