慢性阻塞性肺疾病患者FeNO与外周血IL-8、TNF-α和VEGF水平的相关性研究

Correlation between FeNO and peripheral blood IL-8, TNF-α and VEGF levels in patients with chronic obstructive pulmonary disease* obstructive pulmonary disease*

摘要:

目的 探讨慢性阻塞型肺疾病（COPD）急性加重期患者呼出气一氧化氮（FeNO）的变化，以及与外周血白细胞介素-8（IL-8）、肿瘤坏死因素-α（TNF-α）、血管内皮生长因子（VEGF）水平的相关性。方法 选取2016年3月—2018年5月西宁市第一人民医院收治的COPD急性加重期患者75例为急性观察组，同期门诊65例COPD稳定期患者为稳定对照组，另选取45例该院健康体检者为健康对照组。比较3组受试者FeNO、肺功能及外周血IL-8、TNF-α、VEGF水平，并且分析急性观察组FeNO与外周血IL-8、TNF-α、VEGF水平的相关性。结果 ①急性观察组第1秒用力呼气容积（FEV1）和第1秒用力呼气容积/用力肺活量（FEV1/FVC）低于稳定对照组（P?<0.05），而稳定对照组FEV1和FEV1/FVC低于健康对照组（P?<0.05）；②急性观察组FeNO及外周血IL-8、TNF-α、VEGF水平高于稳定对照组和健康对照组（P?<0.05）；稳定对照组外周血IL-8、TNF-α、VEGF水平高于健康对照组（P?<0.05）；③急性观察组外周血IL-8（r?=0.535，P?= 0.000）、TNF-α（r?=0.313，P?=0.006）及VEGF（r?=0.226，P?=0.049）与FeNO呈正相关。结论 COPD急性加重期患者FeNO及外周血IL-8、TNF-α、VEGF水平高于健康人群和COPD稳定期患者，并且这些指标呈正相关，可能作为临床诊断的指标。

Abstract:

Objective To explore the changes and correlation analysis of fractional exhaled nitric oxide (FeNO) and peripheral blood IL-8, TNF-α, VEGF levels in COPD patients. Methods A total of 75 cases of COPD of acute exacerbations stage in our hospital were selected as observation group, 65 cases of COPD of stable stage in our hospital were selected as control group 1, and 45 healthy people in our hospital were selected as control group 2. The levels of FeNO, lung function and peripheral blood IL-8, TNF-α and VEGF were compared in three groups, and the correlation between FeNO and peripheral blood IL-8, TNF-α and VEGF in observation group was analyzed. Results ① FEV1 and FEV1/FVC in observation group was significantly lower than that in control group 1 (P?