老年慢性阻塞性肺疾病患者合并焦虑抑郁的危险因素分析*

Unconditional Logistic regression analysis of risk factors for anxiety and depression in elderly patients with chronic obstructive pulmonary disease* with HBV related liver cirrhosis

摘要:

目的 探讨老年慢性阻塞性肺疾病（COPD）患者发生焦虑抑郁的可能危险因素。方法 选取2017年1月1日—2018年1月1日江汉大学附属医院（武汉市第六医院）就诊且住院接受治疗的COPD患者120例为研究对象。收集患者性别、年龄、体重指数、学历、病程、病情严重程度等资料，同时采用焦虑抑郁量表对患者进行焦虑抑郁评分。按照评分结果将研究对象分为COPD合并焦虑抑郁组（A组）及不合并焦虑抑郁组（B组）。比较两组各项观察指标，采用非条件Logistic回归分析COPD合并焦虑抑郁的可能危险因素。结果 A组和B组分别为57和63例，焦虑抑郁发生率为47.5%。A组在年龄、病程、体重指数、焦虑及抑郁量表评分与B组比较，差异有统计学意义（P?<0.05），A组高于B组；两组在教育程度、病情轻重、吸烟、独居方面比较，差异有统计学意义（P?<0.05）；在性别比例、来源及是否有独立收入方面比较，差异无统计学意义（P?>0.05）。非条件Logistic回归分析显示，病程、体重指数、吸烟是COPD合并焦虑抑郁的危险因素，分别使COPD患者发生焦虑抑郁风险升高1.434、1.735和6.644倍（P?<0.05）；教育程度高及病情轻为保护因素，分别使COPD合并焦虑抑郁的风险降低0.027和0.140倍（P?<0.05）。结论 COPD合并焦虑抑郁发生率较高，病程长、体重指数高及吸烟是合并焦虑抑郁发生的危险因素，教育程度高及病情轻是保护性因素。

Abstract:

Objective To explore the possible risk factors for anxiety and depression in elderly patients with chronic obstructive pulmonary disease (COPD). Methods Totally 120 cases of COPD patients admitted to Wuhan Sixth Hospital from January 1, 2017 to January 1, 2018 were studied, and their sex, age, body mass index, educational background, course of illness and severity were collected, and the anxiety and depression score of the patients was evaluated by the anxiety and depression scale. According to the score, the subjects were divided into COPD combined with anxiety and depression (group A) and without anxiety and depression (group B). The observation indexes of the two groups were compared. Unconditional Logistic regression analysis was used to analyze the possible risk factors of COPD combined with anxiety and depression. Results Group A and group B were 57 cases and 63 cases respectively. The incidence of anxiety and depression was 47.5%. Compared with the group B, the scores of age, course of disease, body mass index, anxiety and depression scale were significantly higher in group A (P??0.05). The unconditional Logistic regression showed that the course of disease, body mass index and smoking were risk factors for COPD combined with anxiety and depression, which increased the risk of anxiety and depression of COPD patients to 1.434, 1.735 and 6.644 times respectively (P?