解整合素-金属蛋白酶33、1-磷酸鞘氨醇水平与哮喘患者肺功能的关系及其意义

Relationship between serum levels of ADAM33, S1P and pulmonary function in asthmatic patients

摘要:

目的 探讨血清解整合素-金属蛋白酶33（ADAM33）、1-磷酸鞘氨醇（S1P）在哮喘患者中的变化及其意义。方法 选取新乡市中心医院2015年1月—2017年12月收治的120例急性发作期哮喘患者（哮喘组）和60例健康对象（对照组），检测两组研究对象血清中的ADAM33、S1P水平，并根据哮喘病情进行分层分析；分析血清中ADAM33、S1P水平与患者外周血嗜酸性粒细胞（EOS）、免疫球蛋白E（IgE）、第1秒用力呼气容积占预计值百分比（FEV1%）、呼气峰值流速占预计值百分比（PEF%）的关系。结果 哮喘组的血清中ADAM33、S1P水平高于对照组，差异有统计学意义（P?<0.05）；重度哮喘组的血清中ADAM33、S1P水平高于轻-中度患者，差异有统计学意义（P?<0.05）；哮喘组的外周血EOS、IgE高于对照组，差异有统计学意义（P?<0.05），哮喘组的FEV1%、PEF%低于对照组，差异有统计学意义（P?<0.05）；哮喘组的血清S1P与外周血EOS、IgE呈正相关（r?=0.629和0.572，均P?=0.000），哮喘组的血清S1P、ADAM33与FEV1%、PEF%呈负相关（r?=-0.382、-0.411、-0.574和-0.494，均P?=0.000）。结论 急性发作哮喘患者血清S1P、ADAM33水平升高，与患者肺功能降低、哮喘发作程度有关。

Abstract:

Objective To investigate the changes and significance of serum ADAM33 and S1P in asthma patients. Methods Selected 120 patients with acute asthma (asthma group) and 60 healthy subjects (control group) were enrolled in our hospital from January 2015 to December 2017. The levels of ADAM33 and S1P in the serum of the two groups were measured, and stratified analysis was performed according to the condition of asthma; the relationships between the levels of ADAM33, S1P in serum and EOS, IgE, FEV1%, PEF% of patients were analyzed. Results The levels of ADAM33 and S1P in the asthma group were higher than in the control group (P?