CD97 和CD55 在三阴性乳腺癌中的 表达及其临床意义

Expression and clinical significance of CD97 and CD55 in triple negative breast cancer

摘要:

目的 探讨CD97 及其配体CD55 在三阴性乳腺癌（TNBC）中的表达及临床意义。方法 用 免疫组织化学法检测70 例TNBC 组织及50 例正常乳腺组织中CD97 和CD55 的表达，分析其表达与TNBC 临床病理特征的关系。结果 CD97 在TNBC 组织中的表达水平高于正常乳腺组织（P <0.05），其表达与 TNBC 的Ki-67 表达、肿瘤大小、临床分期、脉管癌栓及淋巴结转移相关（P <0.05）。CD55 在TNBC 组织 中的表达水平高于正常乳腺组织（P <0.05），其表达与TNBC 的KI-67 表达、肿瘤大小、临床分期、脉管 癌栓及淋巴结转移相关（P <0.05）。CD97 与CD55 在TNBC 中的表达呈正相关（P <0.05）。结论 CD97、 CD55 可能参与TNBC 的发生、发展过程，其在TNBC 进展中发挥作用，可能成为新的肿瘤标志物。

Abstract:

Objective To investigate the expression and clinical significance of CD97 and its ligand CD55 in triple negative breast cancer (TNBC). Methods The expression of CD97 and CD55 in 70 TNBC tissues and 50 normal tissues were detected by immunohistochemistry. Results The expression level of CD97 in TNBC tissue was significantly higher than that in normal breast tissue (P < 0.05), and its expression was correlated with lymph node metastasis, tumor stages, vascular thrombus, tumor sizes and ki-67 expression in TNBC tissue (P < 0.05). The expression level of CD55 in TNBC tissue was significantly higher than that in normal breast tissue (P < 0.05), and its expression was correlated with lymph node metastasis, tumor stages, vascular thrombus, tumor sizes and ki-67 expression in TNBC tissue (P < 0.05). There was a positive correlation between CD97 and CD55 expression in TNBC (P < 0.05). Conclusions CD97 and CD55 may be involved in the occurrence and development of TNBC, play a role in the progression of TNBC and may become new tumor markers.