抗微生物肽在感染性疾病中的研究进展

Advances in research on antimicrobial peptides in infectious diseases

摘要:

在医学科学高速发展的今天，感染性疾病的发病率仍然很高。由于耐药细菌和变异病毒等不断涌 现，人类寻找新型抗感染药物的脚步也从未停止。抗微生物肽是广泛存在于各种动植物中，具有免疫防御功 能的阳离子多肽类，由于其抗微生物活性多样，具有免疫调节功能，是抗感染药物研发的理想分子。笔者就抗 微生物肽在感染性疾病中的研究现状进行综述。

Abstract:

Although, with rapid development of medical science, the incidence of infectious diseases is still high. Related mortality and huge medical burden still pose a serious threat to human beings. The researches looking for new anti-infective drugs has never stopped with the emergence of drug-resistant bacteria and mutant viruses. Antimicrobial peptides (AMPs) are cationic polypeptides widely existing in all kinds of animals and plants, which play defense and immune function. AMPs are ideal molecules of anti-infection drugs due to their diverse antimicrobial activities and immunoregulatory functions. This article reviews the current research status of AMPs in infectious diseases.