白细胞介素-35 在溃疡性结肠炎中的作用

Role of interleukin-35 in ulcerative colitis

摘要:

白细胞介素-35（IL-35）是白细胞介素-12 异二聚体细胞因子家族的最新成员，由EBI3 和 p35 组成。然而，与其促炎亲属不同，IL-35 具有通过调节性T 细胞和B 细胞介导的免疫抑制作用。虽然关 于IL-35 在人类自身免疫中作用的数据有限，但是一些自身免疫的小鼠模型表明IL-35 可能通过白细胞介 素-10（IL-10）依赖性机制在调节免疫反应性方面起有效作用。该文对IL-35 的结构、信号通路及免疫抑 制作用进行阐述，并总结IL-35 在溃疡性结肠炎中的相关作用。

Abstract:

Interleukin-35 (IL-35) is the latest member of the IL-12 heterodimer cytokine family, which consists of EBI3 and P35. However, unlike its pro-inflammatory relatives, IL-35 has immunosuppressive effects mediated by regulatory T cells and B cells. Although data on the role of IL-35 in human autoimmunity are limit, some mouse models of autoimmunity suggest that IL-35 may play an effective role in regulating immune response through the IL- 10 dependent mechanism. Here we demonstrate the structure, the signalling and the immunosuppressive effect of IL- 35, and we reviewed the the related roles of IL-35 in ulcerative colitis.