二甲硅油给药时机对口服复方聚乙二醇电解质散 肠道准备效果的影响

Effect of timing of administration of simethicone on the preparation of oral compound polyethylene glycol electrolyte

摘要:

目的 探讨二甲硅油给药时机对口服复方聚乙二醇电解质散肠道准备效果的影响。方法 600 例 接受结肠镜检查的患者，采用随机数字表法分为A、B 及C 组，每组200 例。A 组患者于检查前4 h 服用复 方聚乙二醇电解质散139.12 g/2 000 ml 水；B 组患者于检查前4 h 口服相同剂量的复方聚乙二醇电解质散， 服完后即服用二甲硅油散5 g ；C 组患者于检查前4 h 口服相同剂量的复方聚乙二醇电解质散，检查前1 h 服用二甲硅油5 g。比较3 组患者肠道准备评分、肠腔内气泡评分、进退镜时间及结肠镜镜头清晰度评分。 结果 C 组患者肠道准备评分（9.35±0.45）高于A 组（7.95±1.22）和B 组（8.37±0.36）（P <0.05）；C 组 患者肠腔内气泡评分（0.19±0.07）低于A 组（0.45±0.15）和B 组（0.30±0.10）（P <0.05）；C 组患者进退 镜时间（[ 8.15±1.20）和（9.35±0.60）min]短于 A组（[ 10.45±1.65）和（12.11±0.85）min]和B组（[ 9.35±1.22）、 （10.93±0.60）min]（P <0.05）；C 组患者结肠镜镜头清晰度评分（0.78±0.13）低于A 组（1.97±0.26）和 B 组（1.46±0.35）（P <0.05）。3 组在研究过程中无不良事件发生。结论 二甲硅油联合复方聚乙二醇电解质 散可作为一种结肠镜检查前的肠道准备方案。二甲硅油检查前1 h 服用，可有效降低肠腔内气泡量，提升镜检 效率，肠道准备效果更佳。

Abstract:

Objective To investigate the effect of simethicone administration timing on the preparation of oral compound polyethylene glycol electrolyte. Methods A total of 600 patients who underwent colonoscopy were randomly divided into groups A, B, and C, 200 in each group. The three groups were based on compound polyethylene glycol electrolyte 139.12g (2 000 ml) 4 hours before the examination. Group A only took compound polyethylene glycol electrolyte powder, group B took polyethylene glycol electrolyte powder with dimethicone (4h before the examination) and group C took polyethylene glycol electrolyte powder with plus dimethicone (1h before the examination).The intestinal preparation score, colonoscopy bubble score, mirror time, difference in colonoscopy lens clarity and so on were compared among the three groups. Results The gut preparation score (9.35±0.45) in group C was higher than that in group A (7.95±1.22) and group B (8.37±0.36) (P < 0.05); the score of colonoscopy in group C (0.19±0.07) was lower than that in group A (0.45±0.15) and group B (0.30±0.10) (P < 0.05); the time of advance and retreat in group C (8.15±1.20), (9.35±0.60) min was shorter than group A (10.45±1.65), (12.11±0.85) min and group B (9.35±1.22), (10.93±0.60) min (P < 0.05); the colonoscopy lens resolution score (0.78±0.13) in group C was lower than that in group A (1.97±0.26) and group B (1.46±0.35) (P < 0.05). No adverse events occurred in each group during the study. Conclusions Simethicone combined with polyethylene glycol electrolyte can be used as a bowel preparation preparation before enteroscopy. 1 hour before dimethicone examination, it can effectively reduce the amount of air bubbles in the intestine, improve the efficiency of microscopy, and improve the intestinal preparation.