2 型糖尿病伴牙周炎患者牙周基础治疗 对体内代谢的影响

Effect of periodontal treatment on metabolism in patients with type 2 diabetes with periodontitis

摘要:

目的 探讨2 型糖尿病（T2DM）伴牙周炎患者牙周基础治疗对体内代谢的影响。方法 选取 2016 年1 月—2018 年12 月在嘉兴市第一医院口腔科治疗的70 例T2DM 伴牙周炎行牙周基础患者作为观察组， 未行牙周基础治疗的70 例患者作为对照组。测量两组治疗前及治疗后（治疗3 个月后）牙周探诊深度（PD）、 龈沟出血指数（SBI）、附着丧失（AL）值、空腹血糖（FPG）、糖化血红蛋白（HbA1c）、总胆固醇（TC）、 甘油三酯（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、内脂素、瘦素及肿瘤坏死因子-ɑ（TNF-ɑ） 水平。结果 两组治疗前各指标比较，差异无统计学意义（P >0.05）。观察组治疗前后PD、SBI、AL 值低于 本组治疗前和对照组（P <0.05）；而FPG、HbA1c、TC、TG、LDL 及HDL 差值均高于对照组（P <0.05）； 治疗前后血清内脂素、瘦素及TNF-ɑ 差值均高于对照组（P <0.05）。结论 牙周基础治疗可纠正T2DM 伴 牙周炎患者的糖脂代谢紊乱，改善糖脂代谢水平。

Abstract:

Objective To investigate the effect of periodontal treatment on metabolism in patients with type 2 diabetes with periodontitis. Methods Totally 70 patients with type 2 diabetes with periodontitis underwent periodontal treatment were selected as observation group, and 70 patients without periodontal treatment were selected as control group in the Department of Stomatology of the First Hospital of Jiaxing City from January 2016 to December 2018. The periodontal probing depth (PD), sulcus bleeding index (SBI), attachment loss (AL), fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), visfatin, leptin and tumor necrosis factor-ɑ (TNF- ɑ) levels before and after treatment were measured. Results Before treatment, there were no significant differences in each indicators between the two groups (P > 0.05). After treatment, the PD, SBI and AL values in observation group were lower than those before treatment and in control group (P < 0.05); the difference values of FPG, HbA1c, TC, TG, LDL and HDL in observation group were higher than those in control group (P < 0.05); the difference levels of serum Visfatin, Leptin and TNF-ɑ in observation group were higher than those in control group (P < 0.05). Conclusion Periodontal treatment can correct the disorder of glucose and lipid metabolism and improve the level of glycolipid metabolism in patients with type 2 diabetes with periodontitis.