癫痫患者血清S100β、NSE、凋亡因子、炎症因子与脑电图特征的关系研究

Relationship of serum S100β, NSE, apoptotic molecules and inflammatory factors with electroencephalogram in epileptic patients

摘要:

目的 探讨癫痫患者血清S100β、神经元特异烯醇化酶（NSE）、凋亡因子、炎症因子水平与脑电图特征的关系。方法 选取2017年1月—2018年3月青海大学附属医院治疗的癫痫患者99例，其中脑电图正常者17例（脑电图正常组），脑电图界线性者30例（界线性组），脑电图慢波异常者32例（慢波异常组），脑电图癫痫样放电者20例（癫痫样放电组），同时选取健康志愿者40例作为对照组。检测各组S100β、NSE、B淋巴细胞瘤-2（Bcl-2）、Bax、半胱氨酸蛋白酶-3（Caspase-3）、白细胞介素-2（IL-2）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）。结果 癫痫样放电组血清S100β和NSE分别为（6.70±1.44）和（38.89±1.98）ng/ml，高于其他组（P?<0.05）；癫痫样放电组血清Bcl-2为（3.01±0.88）ng/ml，低于其他组（P?< 0.05），而Bax和Caspase-3分别为（3.00±0.42）和（8.10±1.11）ng/ml，高于其他组（P?<0.05）；癫痫样放电组血清Bcl-2、IL-2、IL-6和TNF-α分别为（8.23±1.24）ng/L、（11.78±1.91）ng/L和（6.73±1.21）ng/ml， 高于其他组（P?<0.05）。结论 癫痫患者血清S100β、NSE、凋亡因子、炎症因子水平与脑电图异常改变有一定的关系，值得进一步研究。

Abstract:

Objective To explore the relationship of serum S100β, NSE, apoptotic molecules and inflammatory factors with electroencephalogram in epileptic patients. Methods A total of 99 cases of epileptic patients were treated in our hospital from January 2017 to March 2018, of which 17 cases with normal electroencephalogram (electroencephalogram normal group), 30 cases with linear electroencephalogram (linear group), 32 cases with electroencephalogram slow wave abnormality (slow wave abnormal group) and 20 cases with epileptic discharge (epileptic discharge group). 40 healthy volunteers were selected as control group. S100β, NSE, Bcl-2, Bax, Caspase-3, IL-2, IL-6 and TNF-α in each group were detected. Results The serum S100β and NSE in the epileptic discharge group were (6.70?±?1.44) ng/ml and (38.89?±?1.98) ng/ml, which were significantly higher than those in the control group, the electroencephalogram normal group, the linear group and the slow wave abnormal group (P?< 0.05); the serum Bcl-2 of epileptiform discharge group was (3.01?±?0.88) ng/ml, which were significantly lower than that of the control group, the electroencephalogram normal group, the linear group and the slow wave abnormal group (P?