Hepcidin的研究进展

Research progress of hepcidin

摘要:

摘要： 铁是生物体必需的元素，在氧的携带、细胞内呼吸及其他许多生物代谢途径中发挥着重要的作用。Hepcidin是调节机体铁代谢的关键激素，当机体处于慢性炎症、肿瘤等病理状态时，Hepcidin的合成增加，机体铁代谢失衡造成低铁血症，并且可致慢性病贫血（ACD）发生。许多因子如红细胞生成素（EPO）、白细胞介素-6（IL-6）、生长分化因子15（GDF15)，以及红细胞铁蛋白（ERFE）均可影响Hepcidin的生成。部分肿瘤细胞可合成少量的Hepcidin，通过降低膜铁转运蛋白，限制铁排出肿瘤细胞，与肿瘤的侵袭生长密切相关，因此通过影响Hepcidin的生成来治疗ACD及肿瘤有广阔的应用前景。

Abstract:

Abstract: Iron is an essential element of organisms, and plays important roles in oxygen transport, intracellular respiration and many other biological metabolic pathways. Hepcidin is a key hormone that regulates iron metabolism in the body, when the body is in chronic inflammatory disease, tumor or other pathological conditions, the synthesis of hepcidin increased, and iron metabolism imbalance can caused hypoferriemia, and anemia of chronic disease (ACD). Many factors, such as erythropoietin (EPO), interleukin-6 (IL-6), growth differentiation factor 15 (GDF15) and erythroferrone (ERFE), can affect the production of hepcidin. Some tumor cells can synthesize a small amount of hepcidin too, and limit the iron excretion from tumor cells through reducing the membrane iron transporter, and promote the growth of tumor. Therefore, the strategy of influencing the generation of hepcidin to treat ACD and tumor have broad application prospects.