血浆髓过氧化物酶与房颤射频消融术后复发的关系研究*

Relationship between pre-operative plasma myeloperoxidase level and recurrence of atrial fibrillation in patients after catheter ablation*

摘要:

目的 分析血浆髓过氧化物酶（MPO）与心房颤动（以下简称房颤）患者行射频消融术后复发的关系。方法 前瞻性研究2017年9月—2018年3月中南大学湘雅医院行射频消融治疗的房颤患者45例，术前检测血浆MPO水平并行超声心动图等检查，术后随访1年，根据房颤复发情况分为复发组与未复发组。结果 所有患者随访时间12个月。房颤术后复发率为31.1%（14/45），其中阵发性房颤复发率为25.0%（8/32），持续性房颤复发率为46.1%（6/13）。Cox多因素回归分析显示，术前MPO>50.5?ng/ml与房颤术后复发有关[HlR= 4.292（95% CI：1.153，15.985），P?=0.030]。结论 房颤消融前血浆MPO水平>50.5?ng/ml与术后复发相关。

Abstract:

Objective To investigate the relationship between pre-operative plasma myeloperoxidase (MPO) level and recurrence of atrial fibrillation (AF) in patients after catheter ablation. Methods The prospective study included 45 patients with atrial fibrillation who underwent catheter ablation in our hospital from September 2017 to March 2018. The pre-operative plasma MPO level, echocardiography and other clinical examinations were conducted in all patients. The patients were followed up for 1 year and were divided into recurrent group and non-recurrent group according to the recurrence of atrial fibrillation. Results During 12 months follow-up period, the recurrence rate after atrial fibrillation was 31.1% (14/45), including 25.0% (8/32) of paroxysmal AF and 46.1% (6/13) of persistent AF. Further Cox multivariate regression analysis showed pre-operative MPO > 50.5 ng/ml [HlR = 4.292, (95% CI: 1.153, 15.985, P?=?0.030] was significantly related to AF recurrence. Conclusion Pre-operative plasma MPO level > 50.5?ng/ml is related to AF recurrence in patients after catheter ablation.