男性精神分裂症患者睾酮水平及与认知功能的相关性研究*

Expression of testosterone in male schizophrenics and its correlation with cognitive function*

摘要:

目的 探讨男性精神分裂症患者与健康男性血清睾酮水平表达差异及其与患者认知功能的相关性。方法 选取中国人民解放军102医院男性首发精神分裂症患者64例为研究组，同期健康体检男性57例为对照组。检测两组研究对象的血清睾酮水平，评估认知功能，对检测结果进行相关性分析。结果 研究组血清睾酮水平与对照组比较，差异无统计学意义（P?>0.05）。研究组认知功能测试中，数字划销时间、连线A测试结果高于对照组（P?<0.05），范畴流畅、空间广度、木块图、连续定步调听觉正确数、连续定步调听觉尝试数低于对照组（P?<0.05）。Pearson相关性分析显示，健康男性睾酮水平与数字划销时间、连线A、空间广度、木块图、连续定步调听觉正确数、连续定步调听觉尝试数无相关（P?>0.05），男性精神分裂症患者睾酮水平与数字划销时间、连线A呈正相关（P?<0.05），与空间广度、木块图、连续定步调听觉正确数、连续定步调听觉尝试数呈负相关（P?<0.05），与范畴流畅无相关（P?>0.05）。结论 首发男性精神分裂症患者血清睾酮水平与健康男性无差异。男性精神分裂症患者血清睾酮水平与空间记忆、注意功能呈负相关，可通过调节患者睾酮水平的方法改善其认知功能。

Abstract:

Objective To explore the difference in serum testosterone level between male schizophrenics and healthy male groups, and the correlation between serum testosterone expression and cognitive function. Methods A total of 64 cases of male first-episode schizophrenic patients treated in our hospital from December, 2017 to January 2016 were selected as the study group, and 57 healthy male healthy groups were used as the control group at the same time. Serum testosterone levels were measured in two groups. The cognitive function was measured, and the results of testosterone and cognitive function were compared with parallel correlation analysis. Results The serum testosterone level of the study group was (15.92?±?4.08) nmol/L, and the serum testosterone level of the control group was (15.42?±?3.12) nmol/L, and the difference was not statistically significant (P?>?0.05). In the cognitive function test of the study group, the results of digital delimiting time and connection A test were significantly higher than those of the control group (P??0.05). The testosterone level of male schizophrenics was positively correlated with digital delimitation time and connection A (P?<0.05), but negative with spatial breadth, block diagram, continuous step auditory correct number and continuous step auditory trial number (P??0.05). Conclusions There is no difference in serum testosterone between the first male schizophrenics and the healthy male group (P?>?0.05). The level of serum testosterone in male schizophrenics is negatively correlated with spatial working memory and attention function (P?