Abstract:Objective To explore the mediating effect of mental vulnerability between adolescent self-rating life events check list and interaction anxiousness among undergraduate students, and to provide the basis for effective health intervention. Methods We selected undergraduate students from three colleges in Jinzhou (Jinzhou medical university), Dalian (Dalian medical university) and Shenyang (China Medical University), and A total of 1238 undergraduate students completed a survey that included Mental Vulnerability Questionnaire (MVQ), Adolescent Self-Rating Life Events Check List (ASLEC) and Interaction Anxiousness Scale (IAS). ResuIts The scores of life events, mental vulnerability and interaction anxiousness were (63.94?±?19.06), (46.58?±?13.13) and (34.95?±?9.58), respectively. Life events were positively correlated with mental vulnerability (P?0.05) and interaction anxiousness (P?0.05). Mental vulnerability was positively correlated with interaction anxiousness (P?0.05), and mental vulnerability played a partial mediating role between life events and interaction anxiousness among undergraduate students. Conclusions Life events plays an indirect effect on interaction anxiousness by the mediating effect of mental vulnerability among undergraduate students. Mental vulnerability can reduce the bad effect of life events.