复发性口腔溃疡患者免疫指标、铁代谢指标和肿瘤坏死因子的水平变化特点

Changes in immune indexes, iron metabolism and TNF-alpha levels in patients with recurrent oral ulcers

摘要:

目的 观察复发性口腔溃疡（OC）患者的免疫指标、铁代谢指标和肿瘤坏死因子（TNF-α）水平变化特点。方法 选取2016年10月—2017年10月淮南市第一人民医院收治的OC患者40例为观察组，随机选取同期在该院接受体检的健康成年人40例为对照组。观察两组的免疫指标、血清铁蛋白和TNF-α、超敏C反应蛋白（hs-CRP）等的差异，并分析观察组患者血清铁蛋白与免疫指标、TNF-α等的相关性。结果 观察组患者的免疫球蛋白A（IgA）、免疫球蛋白G（IgG）和免疫球蛋白M（IgM）低于对照组（P?<0.05）；观察组患者的血清铁和铁蛋白低于对照组（P?<0.05）；观察组患者的TNF-α和hs-CRP水平高于对照组（P?<0.05），白细胞介素-2（IL-2）水平低于对照组（P?<0.05）；OC患者的血清铁、铁蛋白水平与IgA、IgG、IgM和IL-2水平呈正相关（P?<0.05），与TNF-α和hs-CRP水平呈负相关（P?<0.05）。结论 OC患者的免疫指标和血清铁蛋白水平较低，TNF-α水平较高，且存在相关关系。

Abstract:

Objective To observe the changes in immune indexes, serum ferritin and tumor necrosis factor alpha (TNF-α) levels in patients with recurrent oral ulcer, and to analyze their clinical values. Methods The patients with recurrent oral ulcers in Huainan First People's Hospital from October 2016 to October 2017 were selected as the research subjects, and the healthy adults who received health examination in our hospital at the same time were selected as the control. The differences among immune indexes, hs-CRP, serum ferritin and TNF-α were observed between the two groups, and the correlations between serum ferritin and the levels of immunologic indexes and TNF-α in patients with recurrent oral ulcer were analyzed. Results The immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM) of the patients in the observation group were lower than those in the control group (P?