慢性萎缩性胃炎危险因素分析

A study on risk factors of chronic atrophic gastritis

摘要:

目的 探讨慢性萎缩性胃炎（CAG）的危险因素。方法 选取2017 年1 月—2019 年2 月在 华北理工大学附属医院消化科经胃镜及病理诊断为CAG 的200 例患者作为萎缩组，经胃镜诊断为慢性非 萎缩性胃炎的200 例患者作为非萎缩组。收集患者性别、年龄、幽门螺旋杆菌（Hp）感染、胆汁反流、嗜 烟、饮酒、药物史及家族史等资料进行单因素及多因素回归分析。结果 萎缩组平均年龄、男性、Hp 阳 性、嗜烟、嗜酒、有药物史、有家族史及有冠状动脉粥样硬化性心脏病史比例高于非萎缩组（P <0.05）。 多因素回归分析显示，有家族史是CAG 的独立危险因素[Ol ^ R=7.181（95% CI ：1.584，32.554）]。CAG 不 同病理阶段在性别、Hp 感染、嗜烟、嗜酒、药物史及家族史等因素比较，差异有统计学意义（P <0.05）。 多因素回归分析显示，Hp 阳性是CAG 病理阶段的独立危险因素[Ol ^ R=2.538（95% CI ：1.459，4.417）]。 结论 CAG 受多方面因素影响，其中家族史及Hp 感染为CAG 的危险因素；Hp 感染更是CAG 病理阶段的 独立危险因素。CAG 患者根除Hp 可获得较多收益。对危险因素进行控制有助于降低CAG 风险。

Abstract:

Objective To explore the risk factors of chronic atrophic gastritis. Method From January 2017 to January 2019, patients in North China University of Science and Technology Affiliated Hospital were collected. 200 patients with chronic atrophic gastritis diagnosed by gastroscopy and pathology were included in the experimental group (CAG group). 200 patients with non-atrophic gastritis diagnosed by gastroscopy were included in the control group. The data of patients were analyzed retrospectively. The factors include sex, age, Hp infection, bile reflux, smoking, alcohol consumption, drug history, family history and so on were analyzed by univariate and multivariate regression analysis. Result The rates of patients with male, old age, Hp infection, bile reflux, smoking, alcohol consumption, drug history, family history were significantly higher than those of control group (P < 0.05). Multivariate regression analysis showed that familial history was an independent risk factor of CAG group [Ol ^ R=7.181 (95% CI: 1.584, 32.554), P < 0.05]. There were significant differences in sex, Hp infection, smoking, drinking, drug history and family history in different pathological stages of CAG (P < 0.05). Multivariate regression analysis showed that positive Hp was an independent risk factor in CAG pathological stage [Ol ^ R=2.538 (95% CI: 1.459, 4.417)]. Conclusion CAG is affected by many clinical factors, and family history and Hp infection are the risk factors of CAG; and Hp infection is the risk factor of pathological stage of CAG. For CAG patients, the eradication of Hp can bring more benefits. Controlling risk factors helps reduce the risk of CAG.