多囊卵巢综合征患者血清Vaspin 水平 及与胰岛素抵抗的相关性分析

Serum Vaspin level in patients with polycystic ovary syndrome and its relationship with insulin resistance

摘要:

目的 研究多囊卵巢综合征（PCOS）患者血清脂肪特异性丝氨酸蛋白酶抑制剂（Vaspin）水平 及其与胰岛素抵抗的关系，探讨其临床意义。方法 选取2016 年1 月—2018 年12 月浙江医院妇产科PCOS 患者96 例作为PCOS 组，选取同期月经规律的健康女性96 例作为对照组。收集两组患者年龄、体重、腰臀 比（WHR）、体重指数（BMI）、空腹血糖（FPG）、空腹胰岛素（FINS）、糖化血红蛋白（HbA1c）、甘油 三酯（TG）及总胆固醇（TC）等临床资料。酶联免疫吸附试验测定血清Vaspin 水平。计算稳态模型胰岛 β 细胞功能指数（HOMA-β）和稳态模型胰岛素抵抗指数（HOMA-IR）。结果 PCOS 组体重、WHR、 BMI 高于对照组（P <0.05）。PCOS 组Vaspin、FPG、FINS、HOMA-β、HOMA-IR 及TG 高于对照组（P <0.05）。 PCOS 患者血清Vaspin 水平与WHR、BMI、FINS、HOMA-IR、TG 呈正相关（r =0.418、0.431、0.387、 0.427 和0.512，P <0.05），与体重、FPG、HOMA-β 无相关性（P >0.05）。结论 PCOS 患者血清Vaspin 水 平升高，其水平与胰岛素抵抗呈正相关。

Abstract:

Objective To investigate the serum lipid-specific serine protease inhibitor (Vaspin) levels and its relationship with insulin resistance in patients with polycystic ovary syndrome in order to explore its clinical significance. Methods From January 2016 to December 2018, 96 patients with PCOS were enrolled in the PCOS group and 96 patients with regular menstruation were enrolled in the control group (C group) in the Department of Obstetrics and Gynecology, Zhejiang Hospital. The age, body weight, waist-to-hip ratio (WHR), body mass index (BMI), fasting blood glucose (FPG), fasting insulin (FINS), glycosylated hemoglobin (HbA1c), triglyceride (TG) and total cholesterol (TC) were collected. The serum Vaspin levels were determined by enzyme-linked immunosorbent assay (ELISA). The steady-state model islet β-cell function index (HOMA-β) and the steady-state model insulin resistance index (HOMA-IR) were calculated. Results The body weight, WHR and BMI of the PCOS group were higher than those of the C group (P < 0.05). The Vaspin, FPG, FINS, HOMA-β, HOMA-IR and TG in the PCOS group were higher than those in the C group (P < 0.05). The serum Vaspin level in patients with PCOS was positively correlated with WHR (r = 0.418), BMI (r = 0.431), FINS (r = 0.387), HOMA-IR (r = 0.427) and TG (r = 0.512) (P < 0.05), and was not associated with body weight, FPG and HOMA-β (P > 0.05). Conclusion The serum Vaspin level is elevated in patients with polycystic ovary syndrome, and its level is positively correlated with insulin resistance.