Turner 综合征垂体MRI 特征 及与激素、染色体的关系

Correlation analysis of pituitary gland MRI with hormone and chromosome in Turner syndrome

摘要:

目的 分析Turner 综合征患儿的垂体磁共振成像（MRI）表现特征及与相关激素、染色体的关系， 探讨垂体改变的原因。方法 选取2010 年6 月－ 2018 年6 月于青岛大学附属医院神经内分泌儿科诊治的43 例 Turner 综合征患儿，回顾性分析垂体MRI 大小与相关激素、染色体的相关性。结果 患儿垂体MRI 多见垂 体正常（22 例，51.2%）和垂体增大（18 例，41.9%）；垂体正常组促卵泡激素、黄体生成素低于垂体增大组 （P <0.05），雌二醇高于垂体增大组（P <0.05）。结论 部分Turner 综合征患儿垂体形态异常，主要表现为垂 体增大，可能与靶腺（卵巢）功能低下引起负反馈抑制作用减弱，导致垂体代偿性增生有关。

Abstract:

Objective To analyze the MRI features of pituitary in children with Turner's syndrome and the relationship with related hormones and chromosomes, and to explore the causes of pituitary changes. Methods Totally 43 children aged 7 to 18 years with Turner syndrome were selected from the Affiliated Hospital of Qingdao university from June 2010 to June 2018. Retrospective analysis of the correlation between MRI size of pituitary gland and both related hormones and chromosomes was performed. Results Most of the patients with pituitary MRI showed normal pituitary (22 cases, 51.2%) and enlarged pituitary (18 cases, 41.9%); the levels of follicle stimulating hormone and luteinizing hormone in the normal pituitary group were lower than those in the enlarged pituitary group (P < 0.05), and estradiol was higher than those in the enlarged pituitary group (P < 0.05). Conclusion Some children with Turner's syndrome have abnormal pituitary morphology, mainly manifested as pituitary enlargement, which may be related to the compensatory hyperplasia of pituitary due to the decrease of negative feedback inhibition caused by the low function of target gland (ovary).