自拟清肺宽胸理气汤对慢性阻塞性肺疾病 急性加重期患者的疗效分析

Analysis of effect of self-made Qingfeikuanxiongliqi decoction in patients with acute exacerbation of chronic obstructive pulmonary disease

摘要:

目的 探讨自拟清肺宽胸理气汤对慢性阻塞性肺疾病（以下简称慢阻肺）急性加重期患者的疗 效。方法 选取2015 年4 月—2018 年5 月成都市第五人民医院收治的91 例慢阻肺急性加重期患者，以随机 法分为对照组和联合组。对照组给予西医治疗，联合组给予西医联合自拟清肺宽胸理气汤治疗。对比两组治 疗前后中医证候积分、肺功能、血气分析指标变化、临床疗效及不良反应。结果 两组治疗后中医证候积 分均低于治疗前（P <0.05），联合组治疗后中医证候积分低于对照组（P <0.05），两组治疗后FEV1、FVC 和 FEV1/FVC 高于治疗前（P <0.05），联合组治疗后FEV1、FVC 和FEV1/FVC 高于对照组（P <0.05），两组治疗 后PaO2 和pH 值高于治疗前（P <0.05），PaCO2 低于治疗前（P <0.05），联合组治疗后PaO2 和pH 值高于对 照组（P <0.05），PaCO2 低于对照组（P <0.05），联合组总有效率高于对照组（P <0.05）。结论 慢阻肺急性 加重期患者在西医治疗的基础上给予自拟清肺宽胸理气汤能够显著控制症状，改善肺功能和血气分析指标， 增强西医治疗效果，且不会增加不良反应。

Abstract:

Objective To explore and analyze the effect of self-made Qingfeikuanxiongliqi decoction on patients with acute exacerbation of chronic obstructive pulmonary disease. Methods A total of 91 patients with acute exacerbation of chronic obstructive pulmonary disease admitted from April 2015 to May 2018 were randomly divided into western medicine group (45 cases) and combination group (46 cases). Western medicine group was treated by western medicine, while the combination group was treated by western medicine combined with self-made Qingfeikuanxiongliqi decoction. The changes of TCM syndrome scores, lung function, blood gas analysis indexes, clinical efficacy and adverse reactions before and after treatment were compared. Results After treatment, while the scores of TCM syndromes and PaCO2 in the two groups decreased (P < 0.05), those in the combined group were lower than those in the western medicine group (P < 0.05). After treatment, FEV1, FVC, FEV1/FVC, PaO2 and pH value of the two groups increased (P < 0.05), and those of the combined group were higher than those of the western medicine group (P < 0.05). The total effective rate of the combined group was higher than that of the western medicine group (P < 0.05). There was no significant difference in the incidences of adverse reactions between the combined group and the western medicine group (P > 0.05). Conclusion On the basis of western medicine treatment, self-made Qingfeikuanxiongliqi decoction can significantly control symptoms, improve pulmonary function and blood gas analysis indexes, enhance the therapeutic effect of western medicine, and will not significantly increase adverse reactions.