聚乙二醇电解质口服溶液联合二甲基硅油对UC患者肠道清洁效果及血清hs-CRP水平的影响

Effect of polyethylene glycol electrolyte oral liquid combined with simethicone on intestinal cleanliness and serum hs-CRP level in patients with ulcerative colitis

摘要:

目的 探讨聚乙二醇电解质口服溶液联合二甲基硅油对溃疡性结肠炎（UC）患者肠道清洁效果及对血清hs-CRP水平的影响。方法 选取2017年3月—2017年7月在宜昌市中心医院接受治疗的96例UC患者，随机分为对照组和观察组，每组48例。对照组服用甘露醇250?ml，观察组服用2?L聚乙二醇电解质口服溶液和50?ml二甲硅油，观察并评估两组患者肠道清洁效果，同时采用ELISA法检测患者血清肿瘤坏死因子-α（TNF-α）、白细胞介素-10（IL-10）、超敏C反应蛋白（hs-CRP）水平。结果 观察组清洁度为Ⅰ、Ⅱ级的患者数分别为27和16例，患者肠道清洁效果优对照组（P?<0.05）。观察组气泡量为Ⅰ、Ⅱ级的患者数分别为31和14例，患者气泡量低于对照组（P?<0.05）。观察组患者治疗后TNF-α、hs-CRP水平低于对照组，IL-10水平高于对照组（P?<0.05）。观察组患者不良反应总数为15次，与对照组比较，不良反应发生率低（P?<0.05）。UC患者治疗前外周血单个核细胞（PBMC）中IL-23受体表达水平与健康人群相比下降（P?<0.05）；观察组患者治疗后IL-23受体表达水平高于对照组（P?<0.05）。结论 聚乙二醇电解质口服溶液联合二甲基硅油的肠道清洁度较高，抑制hs-CRP分泌，改善临床症状，但具体机制仍需要深入探讨。

Abstract:

Objective To explore the effect of polyethylene glycol electrolyte oral liquid combined with two methyl silicone oil on intestinal tract cleaning and the level of hs-CRP in serum of patients with ulcerative colitis (UC). Methods A total of 96 patients with UC treated in our hospital from March 2017 to July 2017 were randomly divided into the control group and the experimental group, with 48 cases in each group. The control group took mannitol 250 ml, the observation group took 2?L polyethylene glycol electrolyte oral liquid and 50 ml simethicone. We observed and evaluated two groups of patients' intestinal cleanliness, intestinal cavity bubble degree and side effects. Meanwhile, Elisa test was used to detect serum levels of tumor necrosis factor (TNF-α), interleukin -6 (IL-6) and hs-CRP. Results The number of patients with I degree, II degree in the observation group was 27 and 16, respectively. The cleaning rate of the experimental group was significantly higher than that of the control group (P?< 0.05). The number of patients with grade I and grade II for volume of bubble in the observation group was 31 cases and 14 cases, and the volume of bubble was significantly lower than that of the control group (P?