调节性B 细胞在吉兰- 巴雷综合征患者 外周血中的表达及意义

Expression and significance of regulatory B cells in peripheral blood of patients with Guillain-Barre syndrome

摘要:

目的 研究吉兰- 巴雷综合征（GBS）患者外周血CD19+CD24hiCD38hiBreg、CD19+CD24hiCD27+ Breg 细胞的变化。方法 选取2018 年10 月—2019 年6 月新疆医科大学第一附属医院昌吉分院收治的GBS 患 者50 例作为GBS 组，选取同期该院健康体检者50 例作为对照组。检测两组外周血CD19+CD24hiCD38hiBreg、 CD19+CD24hiCD27+Breg 的表达。结果 GBS 组CD19+CD24hiCD38hiBreg 细胞表型比例较对照组低 （P <0.05）,GBS 组CD19+CD24hiCD27+Breg 细胞表型比例较对照组低（P <0.05）。结论 GBS 患者外周血 CD19+CD24hiCD38hiBreg、CD19+CD24hiCD27+Breg 细胞减少，其可能参与GBS 的发病，可作为疗效指标之一。

Abstract:

Objective To study the changes of CD19+CD24hiCD38hi Breg and CD19+CD24hiCD27+ Breg cells in peripheral blood of patients with Guillain-Barre syndrome (GBS). Methods Flow cytometry was used to detect the expression of CD19+CD24hiCD38hi Breg and CD19+CD24hiCD27+ Breg in peripheral blood of 50 patients with Guillain-Barre syndrome and 50 healthy controls. Results The phenotype ratio of CD19+CD24hiCD38hi Breg cells in GBS group was lower than that in control group (P < 0.05), and that of CD19+CD24hiCD27+ Breg cells in GBS group was lower than that in control group (P < 0.05). Conclusion Decreased CD19+CD24hiCD38hi Breg and CD19+CD24hiCD27+ Breg cells in peripheral blood of patients with GBS may be involved in the pathogenesis of GBS,which may be an observation index of curative effect.