影响胃癌根治术后患者预后效果的相关因素分析

Analysis of related factors affecting prognosis of patients with gastric cancer after radical resection

摘要:

目的 分析影响胃癌根治术后患者预后效果的相关因素。方法 选取2011 年1 月—2012 年4 月 皖南医学院弋矶山医院收治的胃癌患者200 例，对患者的临床资料进行统计学分析。结果 200 例胃癌患者 中，根治术后1 年生存175 例，3 年生存134 例，5 年生存113 例，生存率分别为87.5%、67.0%、56.5%。患者 不同年龄、手术类型、肿瘤部位、肿瘤直径、术后病理、浸润深度、淋巴结转移、临床分期、神经侵犯、脉 管癌栓及术前白蛋白水平的1、3 和5 年生存率比较，差异有统计学意义（P <0.05），多因素Logistic 回归分析 显示，胃癌患者根治术后预后效果的影响因素包括肿瘤直径[Rl ^ R=1.688（95% CI ：1.266，2.250）]、浸润深度 [Rl ^ R=1.583（95%CI ：1.262，1.986）]、淋巴结转移[Rl ^ R=1.584（95% CI ：1.340，1.872）]。结论 影响胃癌 根治术后患者预后效果的相关因素包括肿瘤直径、浸润深度、淋巴结转移。

Abstract:

Objective To analyze the prognostic factors of patients with gastric cancer after radical resection. Methods The clinical data of 200 cases of patients with gastric cancer from January 2011 to April 2012 in our hospital were analyzed statistically. Results Among the 200 cases of patients with gastric cancer, 175 cases survived after 1 years, 134 cases survived after 3 years, 113 cases survived after 5 years, and the 1, 3 and 5 years survival rates were 87.5%, 67.0% and 56.5% respectively. The differences of 1 year, 3 years and 5 years survival rates between patients with different ages, types of surgery, tumor locations, tumor diameters, postoperative pathology, depth of invasion, lymph node metastasis, TNM stages, perineural invasions, vascular invasions and albumin levels before operation were significant (P < 0.05); multivariate logistic regression analysis showed that the prognostic factors of gastric cancer patients after radical operation included tumor diameter [Rl ^ R = 1.688, (95% CI: 1.266, 2.250)], depth of invasion [Rl ^ R = 1.583, (95% CI: 1.262, 1.986)], lymph node metastasis [Rl ^ R = 1.584, (95% CI: 1.340, 1.872)]. Conclusion The related factors affecting the prognosis of patients with gastric cancer after radical resection include tumor diameter, depth of invasion and lymph node metastasis.