TgAb、TPO-Ab 与首发抑郁症患者 动脉硬化的相关性分析

Correlation between TgAb, TPO-Ab and arteriosclerosis in patients with first-episode depression

摘要:

目的 探讨血清甲状腺球蛋白抗体TgAb、甲状腺过氧化物酶抗体（TPO-Ab）与首发抑郁症患 者动脉硬化的相关性。方法 选取2018 年1 月—2018 年11 月湖州市第三人民医院收治的90 例首发抑郁症 患者，将患者分为TgAb 阳性组、TPO-Ab 阳性组和TgAb、TPO-Ab 均为阳性组，每组30 例。同时随机抽 取甲状腺抗体未见异常的首发抑郁症患者30 例作为对照组。比较各组血清甲状腺激素水平、踝臂指数（ABI）、 肱- 踝动脉脉搏波传导速度（BaPWV）、下肢动脉内中膜（IMT）增厚及斑块发生率。结果 各组BaPWV 比较， 经方差分析，差异有统计学意义（P <0.05）。各组下肢动脉ITM 增厚、斑块形成比例比较，经χ2 检验，差异 有统计学意义（P <0.05），TgAb 阳性组、TPO-Ab 阳性组和TgAb、TPO-Ab 均为阳性组下肢动脉ITM 增厚、 斑块形成例数高于对照组。年龄[Ol ^ R=0.943（95% CI=0.892，0.997）] 和TgAb[Ol ^ R=1.015（95% CI=1.009， 1.022）] 是动脉病变的影响因素。结论 首发抑郁症患者中血清TgAb、TPO-Ab 阳性者的动脉硬化发生率高， 其中TgAb 为下肢动脉硬化的独立危险因素。自动化动脉硬化检测结合血管超声检测有助于首发抑郁症合并 甲状腺自身抗体升高患者动脉硬化风险的筛查。

Abstract:

Objective To explore the correlation between TgAb, TPO-Ab and atherosclerosis in patients with first-episode depression. Methods Ninety patients with first-episode depression hospitalized in Psychosomatic Department of Huzhou Third People's Hospital were included and divided into TgAb-positive group (30 cases), TPOAb-positive group (30 cases) and both antibodies-positive group (30 cases). 30 cases with normal thyroid antibody were selected as control group. The levels of serum thyroid hormone, ABI, BaPWV, the incidence of increased lower extremity artery IMT and plaque were compared. Results After analysis of BaPWV, the difference was statistically significant (P < 0.05). There was significant difference in ITM thickening and plaque formation ratio of lower extremity artery among each group by χ2 test (P < 0.05). The differences of ITM thickening and plaque formation in the lower extremity arteries of all groups were statistically significant (P < 0.05). The number of ITM thickening and plaque formation in the lower extremity arteries of group 1, group 2 and group 3 were higher than that of the control group (P < 0.05). Age [Ol^R = 0.943, (95% CI: 0.892, 0.997)] and TgAb [Ol^R = 1.015, (95%CI = 1.009, 1.022)] were the influencing factors of arterial disease. Conclusion Among patients with first-episode depression, the incidence of arterial sclerosis in serum TgAb and TPO-Ab-positive patients is higher. TgAb is associated with the occurrence of lower extremity arteriosclerosis. Automated arteriosclerosis test combined with vascular ultrasound help screen the risk of arteriosclerosis in patients with first-episode depression with abnormal thyroid autoantibody.