2 型糖尿病患者血清Betatrophin 与周围神经病变的关系

Relationship of serum Betatrophin level with peripheral neuropathy in patients with type 2 diabetes

摘要:

目的 探讨2 型糖尿病（T2DM）患者血清Betatrophin 水平与周围神经病变的关系。方法 选 取2016 年1 月—2016 年11 月在长沙市第一医院就诊的88 例T2DM 患者的临床资料，根据临床症状、体征及 电生理检查，将患者分为58 例糖尿病周围神经病变（DPN）组和30 例未合并DPN（NDPN）组。采用ELISA 法检测血清Betatrophin 水平；分别对两组血压、血糖、糖化血红蛋白、血脂及Betatrophin 等指标进行比较分析， 并对DPN 危险因素行Logistic 回归分析。结果 两组糖尿病病程、血清Betatrophin 水平有差异（P <0.05）。 Logistic 回归分析显示，糖尿病病程、血清Betatrophin 水平是T2DM 患者合并DPN 的独立危险因素（P <0.05）。 结论 T2DM 患者血清Betatrophin 水平与DPN 发生关系密切。

Abstract:

Objective To investigate the relationship of serum Betatrophin level with diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes. Methods A total of 88 type 2 diabetic patients were enrolled into the study. Among them, 58 patients were diagnosed as DPN and 30 patients were diagnosed as non-DPN patients (NDPN) according to clinical symptoms, signs and electrophysiological testing. The serum Betatrophin levels were detected through ELISA. The indexes like blood pressure, blood sugar, HbA1c, blood fat and Betatrophin of two groups were compared. Logistic regression analysis was used for evaluating the related factors of DPN. Results The disease course and serum Betatrophin level between DPN group and NDPN group had statistical significance differences (P < 0.05). Logistic regression analysis revealed that the prolonged disease course and elevated serum Betatrophin level were the risk factors for DPN in patients with type 2 diabetes. Conclusions The serum Betatrophin level is related to the occurrence of DPN in patients with type 2 diabetes.