血清MCP-1、SAA 与老年2 型糖尿病患者 认知功能的相关性研究

Study on the correlation between serum MCP-1, SAA and cognitive function in elderly patients with type 2 diabetes mellitus

摘要:

目的 研究分析血清单核细胞趋化蛋白-1（MCP-1）、淀粉样蛋白A（SAA）与老年2 型糖尿病 （T2DM）患者认知功能的相关性。方法 选取2016 年6 月—2018 年8 月盐城市第一人民医院收治的78 例 老年T2DM 患者作为研究组，另选取同期本院健康体检者70 例作为对照组。采用酶联免疫吸附法检测两组 受试者的血清MCP-1 与SAA 水平，并应用简明精神状态量表（MMSE）评估两组的认知功能，研究分析血 清MCP-1、SAA 水平与T2DM 认知功能的相关性。结果 研究组空腹血糖、糖化血红蛋白水平高于对照组 （P <0.05）。研究组MMSE 的各维度评分低于对照组（P <0.05），且血清MCP-1、SAA 水平高于对照组（P <0.05）。 研究组MMSE 平均得分为（18.16±2.84）分，合并认知障碍发生率为26.92%，轻度、中度和重度认知障碍 组的血清MCP-1、SAA 水平较未合并组升高（P <0.05）。研究组患者的血清MCP-1、SAA 水平与MMSE 总分呈负相关（r s =-0.721 和-0.605，P <0.05）。结论 老年T2DM 患者存在严重认知缺陷，血清MCP-1、 SAA 是老年T2DM 患者发生认知障碍的危险因素，与认知功能呈负相关，可作为评价T2DM 患者认知功能的 非侵入性指标。

Abstract:

Objective To study the correlation between serum monocyte chemoattractant protein-1 (MCP- 1), amyloid A (SAA) and cognitive function in elderly patients with type 2 diabetes mellitus (T2DM). Methods A total of 78 patients with T2DM admitted to our hospital were selected as the study group, and 70 patients with health examination in our hospital during the same period were selected as the control group. The levels of serum MCP-1 and SAA were measured by enzyme-linked immunosorbent assay (ELISA). The cognitive function of the two groups was assessed by the Concise Mental State Scale (MMSE). The correlation between serum MCP-1 and SAA levels and cognitive function of T2DM was studied and analyzed. Results The levels of FBG and HbA1c in the study group were significantly higher than those in the control group (P < 0.05). The scores of MMSE in the study group were significantly lower than those in the control group, and the levels of serum MCP-1 and SAA were significantly higher than those in the control group (P < 0.05). The average score of MMSE in the study group was (18.16±2.84). The incidence of cognitive impairment was 26.92%. Compared with the non-combined group, the levels of serum MCP-1 and SAA in the combined group were significantly higher (P < 0.05); the levels of serum MCP-1 and SAA in the three cognitive impairment groups were significantly higher (P < 0.05). Spersman correlation analysis showed that serum MCP-1 and SAA levels in the study group were negatively correlated with the total score of MMSE scale (r = -0.721 and -0.605, P < 0.05). Conclusions Serum MCP-1 and SAA are risk factors for cognitive impairment in elderly patients with T2DM, which are negatively correlated with cognitive function. They can be used as noninvasive indicators for evaluating cognitive function in elderly patients with T2DM .