Abstract:Corona virus disease 2019 (COVID-19) has become the worldwide outbreak, and the virus has a human susceptibility. The prevention and control of COVID-19 nosocomial infection has become one of the key links in the fight against COVID-19. Anesthesiologists are responsible for the clinical work of patients such as anesthesia, critical care, emergency endotracheal intubation, etc, and participate in the management of outpatient, emergency and inpatients in the other departments. The environment of operating room is special, which is the susceptible department of hospital infection. With the purpose of protecting surgical patients and medical staff, the expert panel of Hunan anesthesia Medical Quality Control Center formulated this programme for prevention and control of SARS-CoV-2 infection during perioperative period and critical care situation.