精神分裂症认知障碍与星形胶质 细胞关系的研究进展

Research progress on the relationship between cognitive impairment and astrocytes in schizophrenia

摘要:

精神分裂症是一种病因未明的、复杂的严重脑部疾病，致残率极高，终身患病率约为0.5%。目前， 精神分裂症阳性症状的药物治疗效果较显著，但阴性症状及认知功能损害的治疗效果仍不理想，这可能与其 复杂的病理机制有关。其中，中枢神经系统中星形胶质细胞的活化与精神分裂症发病机制存在密切联系，与 认知障碍的发生更是关系紧密。因此，明确精神分裂症认知障碍的发病机制及治疗策略迫在眉睫。

Abstract:

Schizophrenia is a complicated and serious brain disease with unknown etiology. The disability rate is extremely high and the lifetime prevalence rate is 0.5%. At present, the drug treatment effect for positive symptoms of schizophrenia is relatively significant, but the treatment effect for negative symptoms and cognitive impairment is still unsatisfactory, which may be related to its complicated pathological mechanism. Among them, the activation of astrocytes in the central nervous system is closely related to the pathogenesis of schizophrenia, especially to the occurrence of cognitive impairment. Therefore, it is urgent to clarify the pathogenesis and treatment strategy of cognitive impairment in schizophrenia. The following is a summary of the recent research progress on the pathological mechanism related to cognitive dysfunction and astrocyte activation in schizophrenia patients.