银杏叶提取物治疗肺纤维化的作用机制

Mechanism of ginkgo biloba extract in the treatment of pulmonary fibrosis

摘要:

肺纤维化是一种原因不明的慢性间质性肺疾病，目前尚无安全有效的治疗方法。银杏叶提取 物（GBE）是从银杏叶中提取的一种化合物，其能对抗大鼠肺纤维化，且安全性高。该文对GBE 抗肺纤维化 的作用机制的研究进展，具体有改善氧化应激、抑制细胞凋亡、调控细胞因子网络（转化生长因子β1、肿 瘤坏死因子-α、结缔组织生长因子等）及基质金属蛋白酶-9/ 金属蛋白酶组织抑制剂-1 系统平衡进行 综述。

Abstract:

Pulmonary fibrosis is a kind of unexplained chronic interstitial lung disease without safe and effective treatment method. Ginkgo biloba extract (GBE), as a compound of gingko leaf extract, have shown against fibrosis in rats with good effect, and high safety. This paper summarized the mechanism of action of ginkgo biloba extract resisting to pulmonary fibrosis, including improving oxidative stress, inhibiting apoptosis, regulation of cytokine network (transforming growth factor-β1, tumor necrosis factor-α and CTGF, etc) and regulation of MMP-9/TIMP-1 system balance. This paper mainly reviews the research progress on the antipulmonary fibrosis mechanism of ginkgo biloba extract.