不同月龄、疾病严重程度的毛细支气管炎患儿血清IL-4、IL-8及外周血T淋巴细胞亚群的变化*

Effects of bronchiolitis severity and age on serum IL-4, IL-8 and peripheral blood lymphocyte subsets in children*

摘要:

目的 探讨呼吸道合胞病毒感染所致的急性毛细支气管炎婴幼儿血清IL-4、IL-8和外周血T淋巴细胞亚群的变化。方法 选取2014年3月—2018年6月广西壮族自治区南溪山医院儿科呼吸道合胞病毒感染的急性毛细支气管炎患儿142例，按疾病严重程度分为轻度组、中度组和重度组，每组再分为≤6个月亚组和>6个月亚组。另选取健康婴幼儿（11例）和排除感染的住院术前准备婴幼儿（26例）共37例设为对照组。观察各组血清IL-4和IL-8的变化及外周血T淋巴细胞亚群相对比例变化情况。结果 重度组的IL-4、IL-8水平在≤6个月亚组和>6个月亚组中最高，与其他组比较，差异有统计学意义（P?<0.05）。重度组CD3+CD4+T淋巴细胞比值高于其他组，其中≤6个月亚组最高；重度组CD3+CD8+和CD3+CD56+T淋巴细胞比值低于其他组，其中≤6个月亚组最低，与其他组比较，差异有统计学意义（P?<0.05）。结论 呼吸道合胞病毒感染所致毛细支气管炎患儿月龄和疾病程度的不同，对血清IL-4和IL-8水平及外周血T淋巴细胞亚群具有影响。

关键词:毛细支气管炎;呼吸道合胞病毒;IL-4;IL-8;淋巴细胞亚群

Abstract:

Objective To investigate the changes of serum IL-4, IL-8 and lymphocyte subsets in infants with acute bronchiolitis caused by respiratory syncytial virus. Methods Totally 142 children with acute bronchiolitis caused by respiratory syncytial virus were recruited from March 2014 to June 2018 in Nanxishan Hospital of Guangxi Zhuang Autonomous region. They were divided into mild, moderate and severe groups according to the severity. Each group was subdivided into ≤6 months subgroup and > 6 months subgroup. A control group was set, which contained Healthy infants (11 cases) and in-hospital preparation infants (26 cases) excluding infection. Serum level of IL-4 and IL-8 and proportion of lymphocyte subsets were measured in each group. Results The levels of IL-4 and IL-8 were the highest in the severe group, and the difference was statistically significant compared with other groups (P?

Key words:bronchiolitis; respiratory syncytial virus; interleukin-4; interleukin-8; lymphocyte subsets