哮喘患儿血清IFN-γ、IL-4、IL-10水平及与肺功能的关系*

Significance of IFN-γ, IL-4 and IL-10 in serum of children with asthma*

摘要:

目的 探讨哮喘患儿血清干扰素-γ（IFN-γ）、白细胞介素-4（IL-4）、白细胞介素-10（IL-10）的变化及其意义。方法 选取2015年1月—2018年8月淮安市妇幼保健院确诊的支气管哮喘急性发作期患儿120例作为哮喘组，选取同期健康儿童60例作为对照组。检测两组的血清IFN-γ、IL-4、IL-10水平，检测的肺功能指标：用力肺活量（FVC）、第1秒用力呼气量（FEV1）、75%呼气中期流量（MEF75%）、50%呼气中期流量（MEF50%）、25%呼气中期流量（MEF25%）、最大呼气峰值流速（PEF）。结果 两组血清IL-4水平比较，差异有统计学意义（P?<0.05），哮喘组高于对照组；两组血清IFN-γ、IL-10、FVC、FEV1、MEF75%、MEF50%、MEF25%、PEF水平比较，差异均有统计学意义（P?<0.05），哮喘组低于对照组；哮喘组血清IFN-γ、IL-10水平治疗前后比较，差异有统计学意义（P?<0.05），治疗后较治疗前升高；哮喘组血清IL-4水平治疗前后比较，差异有统计学意义（P?<0.05），治疗后较治疗前降低；急性发作期哮喘患儿的血清IFN-γ、IL-10水平与FVC、FEV1、PEF均呈正相关（P?<0.05），IL-4水平与FVC、FEV1、PEF呈负相关（P?<0.05）。结论 哮喘组的血清IL-4水平升高、血清IFN-γ、IL-10水平降低，并且与患儿肺功能降低有关。

Abstract:

Objective To investigate the changes and significance of serum IFN-γ, IL-4 and IL-10 in children with asthma. Methods A total of 120 children (asthma group) with acute bronchial asthma and 60 healthy children diagnosed in our hospital from January 2015 to August 2018 were selected as the control group. The levels of serum IFN-γ, IL-4 and IL-10 were measured in the two groups. The lung function indexes were FVC, FEV1, MEF75%, MEF50%, MEF50%, and PEF. Results The serum IL-4 level in the asthma group was significantly different from that in the control group (P?< 0.05), and the asthma group was higher than the control group. The levels of serum IFN-γ, IL-10, FVC, FEV1, MEF75%, MEF50%, MEF25% and PEF in the asthma group were significantly different from those in the control group (P?< 0.05), and the asthma group was lower than the control group. After treatment, the serum levels of IFN-γ and IL-10 in the asthma group were significantly different from those before treatment (P?< 0.05), which were higher than those before treatment. Serum IL-4 levels in the asthma group were significantly different and lower than that before treatment (P?