壮族2型糖尿病患者并发心血管疾病的相关因素分析*

Analysis of risk factors for cardiovascular disease in Zhuang patients with type 2 diabetes*

摘要:

目的 探讨壮族2型糖尿病患者心血管并发症的危险因素。方法 回顾性收集2009年—2018年广西百色市右江民族医学院附属医院、河池市人民医院住院的壮族2型糖尿病患者是否有心血管并发症的相关资料，根据心血管疾病（CVD）诊断标准，将研究对象分为CVD组（n?=628）和非CVD组（n?=1?942）。采用Logistic回归分析壮族2型糖尿病患者CVD风险的危险因素。结果 CVD组年龄、糖尿病病程、空腹血糖（FBG）、餐后2?h血糖（2?hPG）、糖化血红蛋白（HbA1c）、甘油三酯（TC）均高于非CVD组（P?< 0.05）。两组间吸烟史、饮酒史、心血管病家族史方面比较，差异无统计学意义（P?>0.05）；多因素Logistic回归分析结果显示，年龄[OlR=1.062（95% CI：1.052，1.072）]、糖尿病病程[OlR=1.610（95%CI:1.450，1.789）]、 2?hPG [OlR=1.015（95% CI:1.007，1.108）]、HbA1c [OlR=1.225（95% CI：1.107，1.345）]是壮族糖尿病患者并发CVD的危险因素；男性[OlR=0.632（95% CI：0.513，0.776）]和居住在城市[OlR=0.547（95% CI：0.452，0.661）]是2型糖尿病患者CVD的保护因素。结论 女性2型糖尿病患者CVD风险高于男性。年龄、糖尿病病程、2?hPG、HbA1c与壮族糖尿病患者CVD风险呈正相关。早期对高危人群进行筛查有利于降低 2型糖尿病患者CVD的发生风险，降低糖尿病患者的病死率。

Abstract:

Objective To investigate the risk factors of cardiovascular complications in patients with type 2 diabetes mellitus in the Zhuang nationality. Methods The cardiovascular complications related data of Zhuang type 2 diabetes patients hospitalized in the Affiliated Hospital of Youjiang Medical College and Hechi People’s Hospital from 2009 to 2018 were retrospectively collected. According to the diagnostic criteria of cardiovascular disease (CVD), subjects were divided into CVD group (n?=?628) and non-CVD group (n?=?1 942). Logistic regression model was used to analyze the risk factors of CVD risk in Zhuang type 2 diabetic patients. Results The age, duration of diabetes, fasting blood glucose (FPG), postprandial two-hour blood glucose (2 hPG), glycosylated hemoglobin (HbA1c), and triglyceride (TC) were higher in the CVD group than those in the non-CVD group (P??0.05). Multivariate logistic regression analysis showed that age [OlR?=?1.062, (95% CI: 1.052, 1.072)], duration of diabetes [OlR?=?1.610, (95% CI: 1.450, 1.789)], 2 hPG (OlR?=?1.015, (95% CI: 1.007, 1.108)], HbA1c [OlR?=?1.225, (95% CI: 1.107, 1.345)] is risk factors for Zhuang diabetes patients with CVD; males [OlR?=?0.632, (95% CI: 0.513, 0.776)] and living in cities [OlR?=?0.547, (95% CI: 0.452, 0.661)] were protective factors for CVD. Conclusion The risk of CVD in women with type 2 diabetes is higher than that in men. Age, duration of diabetes, 2 hPG, HbA1c were positively associated with CVD risk in Zhuang patients with diabetes. Early screening of high-risk groups was beneficial to reduce the risk of CVD in patients with type 2 diabetes and reduce the mortality of patients with diabetes.