循环肿瘤细胞与泌尿系肿瘤关系的研究进展

Research progress on relationship between circulating tumor cells and urinary tumors

摘要:

循环肿瘤细胞（CTC）在肿瘤传播和转移中起重要作用，最终导致大多数癌症患者死亡。目 前，从癌症患者血液中鉴定和计数CTC 的技术已经将CTC 确立为癌症诊断和预后的重要临床生物标志物。 CTC 具有巨大的潜力，作为非侵入性连续的液体活检技术，相比空间和时间限制的传统组织活检检测恶性肿 瘤更精准。一旦CTC 作为生物标志物用于泌尿系肿瘤患者的精确管理，CTC 的临床应用将更广泛，广大癌 症患者将明显受益。

Abstract:

Circulating tumor cells (CTC) play an important role in tumor spread and metastasis, which ultimately leads to the death of most cancers. Techniques for identifying and counting CTC from the blood of cancer patients have established CTC as important clinical biomarkers for cancer diagnosis and prognosis. CTC have great potential as non-invasive continuous liquid biopsy techniques that may be more representative of the accuracy of individual patient malignancies than traditional tissue biopsy with space and time constraints. Once CTC can be used as biomarkers for the precise management of patients with urinary tumors and for the discovery of new therapeutic agents, the clinical application of CTC will be fully realized and will benefit from a wide range of cancer patient.