右美托咪定对免疫功能的影响及机制回顾

Effects of dexmedetomidine on immune function and its mechanism reviews

摘要:

大多数镇静药对机体免疫功能有抑制作用，这与患者围手术期感染、肿瘤转移和复发等有关。 由于ɑ2 受体激动剂右美托咪定（DEX）对免疫系统的特殊影响，其用于围手术期、脓毒症及肿瘤等具有独 特的临床优势。该文就近10 年来DEX 在动物实验和临床研究中对固有免疫、特异性免疫反应的研究进展作 一综述，包括对巨噬细胞、树突状细胞、NK 细胞、炎症因子、补体及抗体的影响。

关键词:免疫;右美托咪定/ 处方药;炎症

Abstract:

Most sedatives inhibit the function of immune system of the body, and it is closely related to the perioperative infections, tumor metastasis and recurrence. Dexmedetomidine (Dex), as a ɑ2 receptor agonist, due to its effects on the immune system, it has unique clinical advantages in perioperative, sepsis, tumor and other patients. This article reviews the research progress of Dex on the innate immunity and specific immune response of the experimental animals and clinical researches in the past 10 years, including the effects on macrophages, dendritic cells, NK cells, inflammatory cytokines, complement and some antibodies.

Key words:immune; dexmedetomidine / prescription drugs; inflammation