白脂素在代谢性疾病中的作用研究进展

Research progress of asprosin in metabolic diseases

摘要:

白脂素是近年来新发现的脂肪因子，主要功能是诱导肝脏葡萄糖的合成，促进胰岛β 细胞炎症、 功能障碍、凋亡，抑制胰岛素分泌，升高血糖。白脂素与肥胖、2 型糖尿病及多囊卵巢综合征等代谢性疾病的 病理生理过程关系密切。该文对白脂素进行概述，综述其在代谢性疾病中的新作用。

Abstract:

Asprosin is a newly discovered adipokines. Its main function is to induce hepatic glucose synthesis, promote islet β-cell inflammation, dysfunction, apoptosis,inhibit insulin secretion, and raise blood sugar. In recent years, there is increasing evidence that Asprosin is closely related to the pathophysiological processes of obesity, type 2diabetes, polycystic ovary syndrome, and other metabolic diseases. This article reviews the new role of asporsin in metabolic diseases from the overview of Asprosin, its clinical observations of its changes in the above diseases and the possible mechanisms involved.