颅脑损伤患者血清MCP-1 和RANTES 水平及其临床意义

Clinical significance of serum MCP-1 and RANTES levels in patients with traumatic brain injury

摘要:

目的 探讨颅脑损伤患者血清单核细胞趋化蛋白1（MCP-1）和调节活化正常T 细胞表达 和分泌因子（RANTES）水平及其临床意义。方法 选取2019 年1 月—2019 年12 月武警海警总队医院 收治的重型颅脑损伤患者150 例作为颅脑损伤组，选取同期该院健康体检者150 例作为对照组。根据是否 发生主要不良事件分为不良事件组51 例和无不良事件组99 例。测定血清MCP-1、RANTES、C 反应蛋 白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、S100B 水平。结果 颅脑损伤组血 清MCP-1、RANTES、CRP、IL-6、TNF-α 和S100B 水平高于对照组（P <0.05）。颅脑损伤患者血清 MCP-1、RANTES 水平与入院GCS 评分呈负相关（r =-0.627 和-0.634，P <0.05），与血清CRP、IL-6、 TNF-α、S100B 水平呈正相关（MCP-1 ：r =0.516、0.497、0.534 和0.558，P <0.05 ；RANTES ：r =0.542、 0.485、0.497 和0.516，P <0.05）。不良事件组血清MCP-1 和RANTES 水平高于无不良事件组（P <0.05）。 颅脑损伤死亡组血清MCP-1 和RANTES 水平高于存活组（P <0.05）。结论 颅脑损伤患者血清MCP-1 和 RANTES 水平升高，其水平与脑损伤程度、炎症程度、病情严重程度及预后关系密切。

Abstract:

Objective To investigate the serum levels of monocyte chemotactic protein 1 (MCP-1), the regulation of activated normal T cell expression and secretion factor (RANTES) in patients with traumatic brain injury (TBI) and their clinical significance. Methods The prospective controlled study was carried out in 150 patients in the TBI group and 150 healthy people in the control group. Accorded to the occurrence of major adverse events, 150 patients of TBI were divided into adverse event group (51 cases) and non-adverse event group (99 cases). The serum MCP-1, RANTES, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and S100B levels were measured. Results The levels of serum MCP-1, RANTES, CRP, IL-6, TNF-α and S100B in the TBI group were higher than those in the control group (P < 0.05). The levels of serum MCP-1 and RANTES in patients with TBI were negatively correlated with GCS scores (r = -0.627 and -0.634, P < 0.05), and positively correlated with serum CRP, IL-6, TNF-α and S100B levels (MCP-1: r =0.516, 0.497, 0.534 and 0.558, P < 0.05; RANTES: r = 0.542, 0.485, 0.497 and 0.516, P < 0.05). The levels of serum MCP-1 and RANTES in the adverse event group were higher than those in the non-adverse event group (P < 0.05).The levels of serum MCP-1 and RANTES in the death group were higher than those in the survival group (P < 0.05). Conclusions The levels of serum MCP-1 and RANTES in patients with TBI are elevated, and their levels are closely related to the degree of brain injury, inflammation, severity of disease and prognosis.