胶原蛋白Ⅵ在肿瘤中的作用研究进展

Research progress of Collagen Ⅵ in Tumors

摘要:

胶原蛋白Ⅵ是一种细胞外基质蛋白，在多种肿瘤中高度表达，且与临床不良预后相关。胶原蛋 白Ⅵ参与肿瘤的转移与肿瘤的血管重塑，并且通过募集巨噬细胞促进肿瘤炎症。胶原蛋白Ⅵ通过与细胞外基 质其他组分相互作用、刺激信号传导及促进肿瘤代谢重编程，有利于肿瘤的生长。通过肿瘤坏死因子β 途径 减弱肿瘤对程序性死亡[ 蛋白]-1 抑制剂的反应或上调程序性死亡[ 蛋白] 配体-1/ 程序性死亡[ 蛋白]-1， 参与肿瘤的免疫逃逸。此外，胶原蛋白Ⅵ可以促进化疗耐药，这些发现均表明胶原蛋白Ⅵ在肿瘤进展中的重 要作用，为癌症的诊断生物学标志物和癌症治疗靶点的研究提供另一条途径。

Abstract:

Collagen Ⅵ is a extracellular matrix that is highly expressed in numerous tumors and associated with poor clinical outcomes. Many studies indicate that collagen Ⅵ is involved in tumor vascular remodeling and tumor metastasis. And that collagen Ⅵ promotes tumor growth by interacting with other components of ECM, stimulating signal transduction and promoting tumor metabolism reprogramming. We found that collagen Ⅵ was able to participate in tumor immune escape by attenuating tumor response to PDL-1 inhibitors Ⅵa TGF-β pathway or upregulating PDL-1/PD-1 receptor. In addition, collagen Ⅵ plays an important role in chemotherapy. All these findings make clear that collagen Ⅵ is a stimulative factor in tumor progression and strongly support a role for collagen Ⅵ as a new potential biomarker for cancer diagnosis and targets for cancer treatment.