昼夜节律紊乱在动脉粥样硬化发病机制中的 作用及其干预的研究进展

Research progress of circadian rhythm disorder involved in the pathogenesis of atherosclerosis and related interventions

摘要:

生物的日常行为会对周围环境及其昼夜节律变化做出反馈，昼夜节律紊乱参与心血管系统疾病 发生、发展的机制逐渐成为国内外研究的热点之一。心血管系统易受昼夜节律紊乱的影响而发生过度激活或 者不激活，导致各类急性心血管事件的发生。昼夜节律的紊乱被认为是增加罹患心血管疾病风险的关键危险 因素，昼夜节律系统的紊乱可通过影响时钟基因的异常表达、激活或抑制各种细胞因子、改变心血管系统稳 态的方式来导致动脉粥样硬化。通过药物干预等方法可调节机体昼夜节律，改善血压、血脂、纤溶系统及炎 症因子反应来治疗动脉粥样硬化。

Abstract:

The daily behavior of living organisms provides feedback on the surrounding environment and its circadian rhythm. The mechanism of circadian rhythm disturbances in the development of cardiovascular diseases has gradually become one of the hot topics at home and abroad. The cardiovascular system is susceptible to circadian rhythm disturbances that cause excessive activation or inactivation, leading to various types of acute cardiovascular events. A large number of studies have confirmed the characteristics of high incidence of stroke, myocardial infarction and sudden cardiac death in the early morning. Disorders of circadian rhythm are considered to be a key risk factor for increasing the risk of cardiovascular disease. Disorders of the circadian rhythm can be caused by affecting the abnormal expression of clock genes, activating or inhibiting various cytokines, and changing the homeostasis of the cardiovascular system. Atherosclerosis. Pharmacological intervention and other methods can adjust the body’s circadian rhythm, improve blood pressure, blood lipids, fibrinolytic system and inflammatory factor response to treat atherosclerosis.