牛磺熊去氧胆酸预防内镜下胆总管取石术后 结石复发的有效性及安全性分析

Efficacy and safety analysis of tauroursodeoxycholic acid in preventing recurrence of stones after common bile duct stone removal under endoscopy

摘要:

目的 评价牛磺熊去氧胆酸胶囊预防内镜下胆总管取石术后结石复发的有效性及安全性。 方法 选取2016 年3 月—2016 年6 月于兰州市第二人民医院就诊的患者305 例。将患者随机分为试验组与 对照组。试验组应用牛磺熊去氧胆酸胶囊1 粒/ 次，3 次/d ；对照组应用安慰剂胶囊1 粒/ 次，3 次/d。对两 组患者腹部B 超、磁共振胰胆管成像、肝功能、肾功能及血常规进行比较分析。结果 试验组服药6 个月时 总复发率较对照组低（P <0.05），试验组术后1 和2 年总复发率较对照组低（P <0.05）。两组服药前和服药3、 6 个月后的肝功能、肾功能比较，差异无统计学意义（P >0.05），试验组服药前后Cr 比较，差异有统计学意义 （P <0.05），两组服药前和服药3、6 个月后的血常规比较，差异无统计学意义（P >0.05），两组治疗前后的血 常规比较，差异无统计学意义（P >0.05）。共3 例患者出现不良反应，不良反应率为0.98%。结论 牛磺熊去 氧胆酸是预防内镜下胆总管取石术后结石复发有效且安全的药物。

Abstract:

Objective To evaluate the Efficacy and safety analysis of tauroursodeoxycholic acid in preventing recurrence of stones after common bile duct stone removal under endoscopy. Methods A total of 305 patients from 2016.3 to 2016.6 were randomly divided into test group (E) and control group (C). The E group was given Taurolite, 1 capsule/time, 3 times a day. While the C group was given a placebo capsule, 1 capsule/time, 3 times a day. Abdominal B-ultrasonography, MRCP, liver and kidney function, and blood routine were reviewed every three months. Results The 6-month, 1-year, and 2-year follow-up results showed that the total recurrence rate of stones in the test group was less than that in the control group, which was statistically significant (P < 0.05). There was no significant difference in liver function and renal function between the two groups before and after taking medicine for 3 and 6 months (P > 0.05), but there was significant difference in Cr before and after treatment in the experimental group (P < 0.05); and there was no significant difference in blood routine before and after taking medicine for 3 and 6 months (P > 0.05). There were no significant changes in blood routine indexes before and after medication between the two groups (P > 0.05). There were 3 cases of adverse reactions, and the adverse reaction rate was 0.98%. Conclusions Tauroursodeoxycholic acid is an effective and safe drug in prevention of recurrent bile duct stones after endoscopic clearance of common bile duct stones.