原发性肝细胞癌中Ezrin和Survivin的表达及其与淋巴结转移的关系*

Expression of Ezrin and Survivin in primary liver cancer and its relationship with metastasis*

摘要:

目的 探讨原发性肝细胞癌中Ezrin和Survivin的表达及其与淋巴结转移的相关性。方法 选取2014年3月—2018年5月右江民族医学院附属医院接受手术切除的原发性肝细胞癌患者98例，采集组织石蜡标本，其中淋巴结转移58例，无淋巴结转移40例。9例肝组织正常样本采自正常肝组织。检测不同分组Ezrin 和Survivin的表达水平。结果 正常对照组、无淋巴结转移肝癌组及有淋巴结转移肝癌组中Ezrin阳性表达率分别为33.3%、42.5%和69.0%，有淋巴结转移肝癌组Ezrin的表达水平高于无淋巴结转移肝癌组（P?<0.05）。正常对照组、无淋巴结转移肝癌组及有淋巴结转移肝癌组Survivin阳性表达率分别为0.0%、50.0%和84.5%，有淋巴结转移肝癌组Survivin的表达水平高于正常对照组和无淋巴结转移肝癌组（P?<0.05）。Spearman法相关性分析提示，Ezrin与Survivin的表达与淋巴结转移呈正相关（P?<0.05）。结论 Ezrin与Survivin在原发性肝细胞癌中的高表达与原发性肝细胞癌的侵袭性行为关系密切，可作为评估早期原发性肝细胞癌预后的指标之一。

Abstract:

Objective To investigate the expression of Ezrin and Survivin in primary liver cancer and its correlation with metastasis. Methods A total of 98 paraffin-embedded specimens of primary liver cancer were surgically removed from March 2014 to May 2018. Among these, 58 cases were metastasized and 40 cases were non-metastatic. Nine cases of normal liver tissue were collected from normal liver tissue. The expression levels of different groups Ezrin and survivin were detected. Results The positive expression rates of Ezrin in normal control group, non-metastatic liver cancer group and metastatic liver cancer group were 33.3%, 42.5% and 69.0%, respectively. The expression level of Ezrin in metastatic liver cancer was higher than that in non-metastasis liver cancer group (P?