子宫螺旋动脉超声联合血清TGF-β1、IGF-1水平预测早发型子痫前期的临床价值

Clinical value of uterine artery ultrasound combined with serum TGF-β1 and IGF-1 in predicting early onset preeclampsia dialysis patients*

摘要:

目的 探讨子宫螺旋动脉超声联合血清转化生长因子β1（TGF-β1）、胰岛素生长因子-1（IGF-1） 预测早发型子痫前期的临床价值。方法 选取2015年3月—2018年3月延安大学附属医院收治的早发型子痫前期孕妇（研究组）和正常孕妇（对照组），每组60例。所有患者均行子宫螺旋动脉超声检查，并采用酶联免疫吸附试验（ELISA）检测血清TGF-β1、IGF-1表达水平，采用Logistic回归模型结合受试者工作特征（ROC）曲线评价联合检测对早发型子痫前期诊断的临床价值。结果 两组血压和搏动指数（PI）比较，差异有统计学意义（P?<0.05），研究组高于对照组；两组血清TGF-β1和IGF-1表达水平比较，差异有统计学意义（P?< 0.05），研究组患者血清TGF-β1表达水平高于对照组，IGF-1表达水平低于对照组；联合检测ROC曲线下面积分别为0.887（95% CI：0.821，0.932），子宫螺旋动脉超声、血清TGF-β1、IGF-1单独诊断的ROC曲线下面积依次为0.765（95% CI：0.758，0.885）、0.733（95% CI：0.717，0.864）、0.675（95% CI：0.615，0.846），联合检测ROC曲线下面积高于其他3种单独诊断方式，差异有统计学意义（Z?=2.314，P?=0.021）。结论 子宫螺旋动脉超声联合血清TGF-β1、IGF-1检查可提高早发型子痫前期患者诊断的敏感性，对于早发型子痫前期患者早期诊断具有潜在的应用价值。

Abstract:

Objective To investigate the clinical value of uterine artery ultrasound combined with serum transforming growth factor β1 (TGF-β1) and insulin-like growth factors (IGF-1) in predicting early preeclampsia. Methods Sixty pre-eclampsia pregnant women and 60 normal pregnant women admitted to our hospital from March 2015 to March 2018 were enrolled as study group and control group. Uterine artery ultrasonography was performed in all patients, serum TGF-β1 and IGF-1 expression levels were measured by enzyme-linked immunosorbent assay (ELISA), and the logistic regression model was combined with the receiver operating characteristic curve (ROC) to evaluate the clinical value of combined detection for the early diagnosis of early onset eclampsia. Results The blood pressure and PI values of the study group were significantly higher than those of the control group (P?