NRG1/ErbB4信号通路与精神疾病关联的研究进展*

Recent advances in psychiatric disorder associated with NRG1/ErbB4 signalling pathway*

摘要:

在中枢神经系统中，神经调节素1（NRG1）可激活其ErbB受体，影响神经元的发育和迁移，突触的形成、成熟以及突触可塑性。许多研究表明，NRG1与ErbB4基因为精神疾病的易感基因。最早与精神分裂症关联，随后与双向情感障碍、焦虑、抑郁的联系也被逐渐发现。该文通过对NRG1/ErbB4信号通路在中枢神经系统的作用及其与多种精神疾病相关性的研究进行综述，以期为相关精神疾病带来更多的研究思路。

Abstract:

In central nervous system, neuroregulins1 (NRG1) is a ligand of ErbB tyrosine kinase receptors, activates downstream signaling pathways and influences neuronal cell development and migration, synapse formation and maturation as well as synaptic plasticity. NRG1 and ErbB4 genes are both susceptible genes for neuropsychiatric disorders. After being associated with schizophrenia and bi-polar disorder, their influence in anxiety and depression were gradually discovered. We reviewed NRG1/ ErbB4 signaling pathway function in central nervous system and related psychiatric research to promote more investigations of this field.