外周血炎症标志物联合T淋巴细胞亚群检测在新型冠状病毒肺炎的临床价值探讨

Clinical value of blood inflammatory markers combined with T lymphocyte subsets in the detection of novel coronavirus pneumonia

摘要:

目的 探讨白细胞（WBC）、C反应蛋白（CRP）和降钙素原（PCT）联合T淋巴细胞亚群检测在诊断新型冠状病毒肺炎（COVID-19）及细菌性肺炎中的临床价值。方法 回顾性分析COVID-19患者35例（COVID-19组）和细菌性肺炎患者40例（细菌性肺炎组）的临床资料，比较两组血常规、CRP、PCT、T淋巴细胞亚群值，并分析两组患者的临床资料及特征。结果 COVID-19组患者血WBC、淋巴细胞绝对值、CRP、PCT水平均低于细菌性肺炎组（P?<0.05）；COVID-19组CD3、CD4、CD8细胞绝对计数均低于细菌性肺炎组（P?<0.05）；而两组CD4/CD8比较，差异无统计学意义（P?>0.05）。结论 联合检测外周血常规、CRP、PCT及T淋巴细胞亚群有助于COVID-19、细菌性肺炎的鉴别诊断，尤其在COVID-19疫情期间，对临床症状不典型的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染及疑似患者具有重要临床意义。

Abstract:

Objective To summarize the clinical characteristics of COVID-19 (Corona virus disease 2019) and bacterial pneumonia, and to explore the clinical value of white blood cell (WBC), C-reactive protein (CRP) and procalcitonin (PCT) combined with detection of T lymphocyte subgroup in the detection of novel COVID-19 and bacterial pneumonia. Methods The clinical data of 35 patients with COVID-19 and 40 patients with bacterial pneumonia were retrospectively analyzing, and all patients were tested for blood routine, CRP and PCT, T-lymphocyte subsets. The clinical data and characteristics of the two groups were analyzed. Results The levels of WBC, absolute value of lymphocytes, CRP and PCT in the COVID-19 group were significantly lower than those in the bacterial pneumonia group, and the difference between the two groups was statistically significant (P??0.05). Conclusions The combined detection of peripheral blood routine, CRP, PCT and T lymphocyte subsets is helpful for the differentiation of COVID-19 and bacterial pneumonia, especially during the outbreak of novel coronavirus pneumonia, which has important clinical significance for SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection with atypical clinical symptoms and suspected patients.