肿瘤倍增时间在非小细胞肺癌患者预后评价中的作用

Role of tumor doubling time in prognosis evaluation of patients with non-small cell lung cancer

摘要:

目的 探讨肿瘤倍增时间（TDT）在非小细胞肺癌（NSCLC）患者预后评价中的作用。方法 回顾性分析选取2012年1月—2014年5月华北理工大学附属唐山市人民医院接受NSCLC手术切除的患者247例， 收集患者术前2次及以上胸部薄层CT扫描图像。使用Schwartz公式计算肺癌的TDT，探究TDT的长短与其病理生长特点、组织学类型、分化程度等因素的关系。使用Kaplan-Meier生存方法绘制TDT与总生存期（OS）、无复发生存期（RFS）之间的关系曲线图，分析患者生存期。结果 TDT<400?d组中肿瘤直径>3?cm、 低分化和实性密度肿瘤患者的比例高于TDT≥400?d组（P?<0.05）；TDT≥400?d组中女性、无吸烟史和腺癌患者的比例高于TDT<400?d组（P?<0.05）；两组的年龄、血清癌胚抗原（CEA）、肿瘤部位比较，差异无统计学意义（P?>0.05）；TDT≥400?d组的OS和RFS优于TDT<400?d组（P?

Abstract:

Objective To investigate the role of tumor doubling time (DT) in the prognosis evaluation of patients with non-small cell lung cancer (NSCLC). Methods A retrospective analysis of 247 patients who underwent surgical resection of non-small cell lung cancer was performed with a thin-slice CT scan of the chest two or more times before surgery. The Schwartz formula was used to calculate the tumor doubling time (TDT) of lung cancer, and to explore the relationship between the length of TDT and its pathological growth characteristics, histological type and degree of differentiation. The Kaplan Meier survival method was used to map the relationship between TDT and OS and RFS, and the patients' survival time was analyzed. Results The proportion of patients with tumor diameter > 3?cm, poorly differentiated and solid density in TDT < 400?d group was higher than that in TDT ≥ 400?d group, the difference was statistically significant (P??0.05). The overall survival (OS) and the recurrence-free survival (RFS) of the TDT≥ 400?d group were better than the TDT < 400?d group, and the differences were statistically significant (P?