小分子Janus 激酶抑制剂在炎症性肠病中的应用

Research progress of small molecule Janus kinase inhibitors in inflammatory bowel disease

摘要:

Janus 激酶是细胞内酪氨酸激酶，在许多参与免疫的细胞因子的信号传导途径中起着关键作用。 JAK-STAT 信号通路对于细胞的增殖、凋亡及免疫调节等起到了重要作用，目前与疾病及药物创新相干的研 究都集中于炎症疾病及肿瘤疾病。JAK 激酶可能成为炎症性肠病治疗的新靶点。该文就小分子Janus 激酶抑 制剂在炎症性肠病中的应用做一综述。

Abstract:

Janus kinase (JAK) is a tyrosine kinase in cells, which plays a key role in many signal transduction pathways of cytokines involved in immunity. JAK-STAT signaling pathway is importantly engaged in cell proliferation, apoptosis, immune regulation and other processes. Currently, studies related to diseases and drug innovation are focused on inflammatory diseases and cancer which can be exemplified by inflammatory bowel disease. JAK may become a new target for the treatment of inflammatory bowel disease. This article reviews the application of small molecule Janus kinase inhibitors in inflammatory bowel disease.